LASER TATTOO REMOVAL SYSTEM USING DERMAL CLEARING AGENT

描述：(逐字)-近年来，纹身的流行 增长惊人，现在据信有1000多万美国人拥有一台或 更多的纹身。随之而来的是对纹身的需求增加 去掉纹身。激光去除纹身的一个限制是激光是 在去除红色和黄色油墨方面最有效的也是高度分散的 通过组织，因此它们的输送效率较低。在所有情况下，降低 辐射传输的效率要求采用多种治疗方法。 在这一阶段的研究中，我们建议增加激光纹身的效果 通过引入一种药物进行治疗，这种药物可以暂时和显著地减少 分散在真皮和表皮中。光学散射的减小 介入皮肤的系数增加了总体效果 皮肤的透过率，并允许激光更好地穿透到 目标纹身墨水。反过来，这又允许较低的辐射剂量水平 以及减少非特定供暖。在本项目中，我们将比较 我们新的治疗方法比传统的激光纹身治疗方法更有效 成熟的动物模型。我们预计这一努力将导致 开发一种双波长系统，利用皮肤透明来更多地 有效去除纹身。 建议的商业应用： 建议的技术可以提高激光纹身去除的效率， 将使这一过程更快、更负担得起，因此更容易获得。此外， 这项技术对其他应用具有潜在的重要性，包括脱毛、波特温 污渍处理，以及“蜘蛛”静脉的处理。这类手术的市场潜力 目前每年超过7.5亿美元，随着速度和效率的提高， 应该会大幅增加。制定和发展交付方法 因为皮肤清洗剂代表了使能技术，这将是关键的一部分 商业纹身去除疗法。

DESCRIPTION: (Verbatim) - In recent years, the popularity of tattooing has grown tremendously with over 10 million Americans now believed to have one or more tattoos. Along with this demand for tattoos comes an increased demand for tattoo removal. A limitation of laser tattoo removal is that lasers which are most effective at removing red and yellow inks are also more highly scattered by tissue and their delivery is therefore less efficient. In all cases, reduced efficiency of radiation delivery mandates multiple treatments. In this phase I study we propose to increase the efficacy of laser tattoo treatment by introducing an agent which temporarily and dramatically reduces scatter in the dermis and epidermis. Reduction of the optical scattering coefficient of the intervening skin increases the overall effective transmittance of the skin and allows for better penetration of the laser to the target tattoo inks. In turn, this allows for lower irradiation fluence levels and a reduction in non-specific heating. In this project, we will compare the efficacy of our new treatment to that of conventional laser tattoo treatment in well-established animal models. We expect this effort to lead toward the development of a dual wavelength system that utilizes dermal clearing to more efficiently remove tattoos. PROPOSED COMMERCIAL APPLICATION: The proposed technology could lead to improved efficiency of laser tattoo removal which will make this procedure faster, more affordable, and therefore more accessible. Further, the technique has potential importance to other applications including hair removal, portwine stain treatment, and treatment of "spider" veins. The market potential of such procedures currently exceeds $750 million annually, and with improved speed and effectiveness, should increase dramatically. Formulation of and development of a delivery methodology for dermal clearing agents represent enabling technologies which will be a crucial part of commercial tattoo removal therapy.