Retinal Microvascular Characteristics/Vascular Disorders

描述：(申请人摘要)本建议书描述了一项附属的 基于社区动脉粥样硬化风险(ARIC)研究的分析性研究 基于新的知识，表明视网膜微血管 疾病与女性发生冠心病有关，而突发事件 男性和女性中的中风，与已确定的心血管风险无关 各种因素。本拟议研究现在的目的是描述 视网膜微血管疾病(视网膜小动脉狭窄、动静脉病变 划痕、视网膜病变)到突发高血压、突发糖尿病以及 其他与年龄相关的血管疾病(认知功能减退、肾功能障碍和 脑白质损害)。研究人群来自15,792人 ARIC研究的参与者，这是一个具有良好特征的混合种族男性队列 和45-岁的妇女，她们在1987-89年间首次接受检查(基线)和 此后每三年进行一次访问，共四次。在…的过程中 四次随访和持续的年度随访监测，高血压 和糖尿病通过标准化的历史问卷进行评估，体检 检查和实验室测试；通过以下方法评估认知功能 神经心理测试；肾功能通过血清肌酐进行评估 测量；和脑白质损害和萎缩的评估 对一个人的样本进行大脑核磁共振检查。 这项研究将包括一系列新的分析，以详细评估 视网膜微血管异常与这些疾病的关系。这 将包括纵向(视网膜异常与事件的关系 高血压和糖尿病)和横断面(视网膜的关系 认知障碍、肾功能障碍和脑白质异常 物质损伤和萎缩)分析。预计对于其中的每一个， 必须构建单独的数据集，定义变量，并 进行单独的分析。建议的工作超出了原来的范围。 分析视网膜病变与冠心病和中风的关系。这 格兰特将为拟议的分析提供必要的资金， 利用已经收集的广泛的ARIC研究数据 十年了，在其他地方是买不到的。这项研究将提高对 微血管疾病与发展性高血压的关系， 糖尿病和其他与年龄相关的血管疾病，具有代表性 男人和女人的人口。

DESCRIPTION: (Applicant's Abstract) This proposal describes an ancillary analytical study based on the Atherosclerosis Risk in Communities (ARIC) study cohort, builds upon new knowledge that suggest that retinal microvascular disease is related to incident coronary heart disease in women, and incident stroke in men and women, independent of established cardiovascular risk factors. The present proposed study is now aimed at describing the relation of retinal microvascular disease (retinal arteriolar narrowing, arterio-venous nicking, and retinopathy) to incident hypertension, incident diabetes, and other age-related vascular disorders (cognitive decline, renal dysfunction, and cerebral white matter lesions). The study population is derived from the 15,792 participants of the ARIC study, a well-characterized bi-racial cohort of men and women 45-64 years of age, who were first examined in 1987-89 (baseline) and every three years thereafter for a total of four visits. During the course of the four visits and the continuing annual follow-up surveillance, hypertension and diabetes were evaluated by a standardized history questionnaire, physical examination, and laboratory tests; cognitive function was evaluated by neuropsychological tests; renal function was evaluated by serum creatinine measurement; and cerebral white matter lesions and atrophy were evaluated by cerebral MRI on a sample of persons. The study will comprise a series of new analyses to evaluate in detail the association of retinal microvascular abnormalities to these disorders. This will include both longitudinal (relation of retinal abnormalities to incident hypertension and incident diabetes) and cross-sectional (relation of retinal abnormalities to cognitive impairment, renal dysfunction, and cerebral white matter lesions and atrophy) analyses. It is anticipated that for each of these, individual data sets will have to be constructed, variables defined, and separate analyses performed. The work proposed goes beyond the original analyses relating retinal findings to coronary heart disease and stroke. This grant will provide necessary funds specific to the proposed analyses, capitalizing on the extensive ARIC study data already collected over more than ten years, and unavailable elsewhere. This study will improve the understanding of the relation of the microvascular diseases to the development hypertension, diabetes, and other age-related vascular conditions, in representative populations of men and women.