Novel Risk Factors for Chronic Kidney Disease

慢性肾脏病的新危险因素

• 批准号: 7139753
• 负责人: RONALD KLEIN
• 金额: $ 38.67万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-20 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7139753
• 关键词: aging; biomarker; cardiovascular disorder; chronic disease /disorder; clinical research; disease /disorder proneness /risk; glomerular filtration rate; human data; human middle age (35-64); human old age (65+); human tissue; inflammation; kidney disorder; longitudinal human study; microcirculation; oxidative stress; retina circulation; vascular endothelium

DESCRIPTION (provided by applicant): This application is written in response to Program Announcement PA-03-091, "Ancillary Studies of Kidney Disease Accessing Information from Clinical Trials, Epidemiological Studies, and Databases". Its aims are to determine the relation of: (1) biomarkers of inflammation (high sensitivity C-reactive protein, interleukin 6, tumor necrosis factor-alpha Receptor 2); (2) biomarkers of oxidative stress (plasma free F2-isoprostanes, plasma protein carbonyl content); (3) biomarkers of endothelial dysfunction (E-selectin, intercellular adhesion molecule 1, vascular cell adhesion molecule 1); and (4) retinal microvascular diameters to estimated glomerular filtration rate (GFR), 15-year change in estimated GFR, and the development of incident chronic kidney disease (CKD) over a 15-year interval. This project is designed as an ancillary study to the Beaver Dam Studies. The information necessary to test the specific aims of the project will be obtained by combining new data from stored laboratory measures and data already collected in the Beaver Dam Studies, ongoing population-based studies of persons 43-86 years who were examined at 5-year intervals beginning in 1988- 1990.. The design will be a nested case-cohort study within the Beaver Dam Studies. We anticipate 269 cases of incident CKD and will select 1150 persons for the random sample. Incident CKD will be defined as an estimated GFR<60 mL/min per 1.73 meter[2]. The estimated GFR will be calculated using the Modification of Diet in Renal Disease equation. Baseline frozen plasma samples will be batch-analyzed for biomarkers of inflammation, endothelial dysfunction, and oxidative stress. Retinal vessel diameters have been measured using a computer-assisted program. Data from this study will provide a unique opportunity to evaluate the relationship of inflammation,, oxidative stress, endothelial dysfunction, microvascular characteristics and CKD. The new data may provide insights into the relative protective value of low levels of these markers on the incidence CKD in an aging population.

描述（由申请人提供）：本申请是根据项目公告PA-03-091“肾脏疾病辅助研究--从临床试验、流行病学研究和数据库中收集信息”编写的。其目的是确定：（1）炎症生物标志物（高敏C反应蛋白、白细胞介素6、肿瘤坏死因子-α受体2）;（2）氧化应激的生物标志物（血浆游离F2-异前列腺素，血浆蛋白羰基含量）;（3）内皮功能障碍的生物标志物（E-选择素，细胞间粘附分子1，血管细胞粘附分子1）;和（4）视网膜微血管直径与估计的肾小球滤过率（GFR），估计的GFR的15年变化，以及在15年的时间间隔内偶然发生慢性肾脏疾病（CKD）。本项目旨在作为比弗坝研究的辅助研究。将通过将来自储存的实验室测量的新数据与比弗坝研究中已经收集的数据相结合来获得测试该项目具体目标所需的信息，比弗坝研究是对43-86岁的人进行的以人口为基础的研究，从1988- 1990年开始每隔5年进行一次检查。设计将是比弗坝研究中的嵌套病例队列研究。我们预计将有269例CKD病例，并将选择1150人进行随机抽样。新发CKD定义为估计GFR<60 mL/min/1.73米[2]。将使用肾脏疾病饮食改良公式计算估计的GFR。将对基线冷冻血浆样本进行炎症、内皮功能障碍和氧化应激生物标志物的批分析。视网膜血管直径已使用计算机辅助程序进行测量。这项研究的数据将提供一个独特的机会，以评估炎症，氧化应激，内皮功能障碍，微血管特征和CKD的关系。新的数据可能会提供见解的相对保护价值低水平的这些标志物的发病率CKD在老龄化人口。