Epidemiology of Diabetic Retinopathy
Epidemiology of Diabetic Retinopathy
批准号:
7112252
负责人:
RONALD KLEIN
金额:
$82.21万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-09-01 至 2009-07-31
关键词:
acute phase proteinamputationbiomarkerblood pressurecell adhesionclinical researchdepressiondiabetes mellitusdiabetic retinopathyedemaepidemiologyeye fundus photographyhuman subjectinflammationinsulin sensitivity /resistanceinterleukin 6intraocular pressurelimbslongitudinal human studymedical complicationmyocardial infarctionpatient oriented researchquality of lifequestionnairesretina disordertumor necrosis factor alphavision disordersvision tests
中文摘要
描述(由申请人提供):本流行病学研究旨在:(1)确定1型糖尿病患者糖尿病视网膜病变的累积15年进展和增殖性视网膜病变、黄斑水肿、视力损害、其他微血管(糖尿病肾病)和大血管(心肌梗死、下肢截肢)并发症的发生率,并量化这些结果的风险,包括炎症标志物、内皮功能障碍、细胞粘连和估计的胰岛素抵抗;(2)检验10年以上1型糖尿病患者视力变化与自评健康和自评视力目标生活质量的关系;(3)研究1型糖尿病患者视觉障碍与抑郁的横断面关联。该研究建立在以人群为基础的威斯康辛糖尿病视网膜病变流行病学研究(WESDR, NEIR01 03083)的基础上,该研究包括了1979-1980年在威斯康辛州西南部11个县接受初级医疗保健的所有胰岛素摄入1型糖尿病患者。分别于1980-82年、1984-86年、1990-92年、1995-96年和2000-01年进行检查。
英文摘要
DESCRIPTION (provided by applicant): This epidemiological study aims to: (1) determine the cumulative 15-year progression of diabetic retinopathy and incidence of proliferative retinopathy, macular edema, visual impairment, other microvascular (diabetic nephropathy) and macrovascular (myocardial infarction, lower extremity amputation) complications in persons with type I diabetes and quantify the risk of these outcomes with regard to markers of inflammation, endothelial dysfunction, cellular adhesion and of estimated insulin resistance; (2) examine the association of change in visual acuity and changes in self-rated health and self-reported visual-targeted quality of life in type 1 persons with long term diabetes over a ten year period; and (3) examine the cross-sectional association of visual impairment and depression in persons with type 1 diabetes. The study builds upon the population-based Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR, NEIR01 03083) which included all insulin-taking persons with type 1 diabetes and who were receiving primary medical care in an 11-county area of southwestern Wisconsin in 1979-1980. Exams were performed in 1980-82, 1984-86, 1990-92, 1995-96, and 2000-01.
These persons will be examined in their communities in a mobile examining van. Refraction, visual acuity, intraocular pressure, blood pressure and other measurements will be obtained according to standardized protocols. Objective recording of retinopathy from stereoscopic fundus photography combined with a standardized grading will be used. Standardized questionnaires including the SF-36, the NEI-VFQ 25, and the Center for Epidemiologic Studies Depression Scale (CES-D) will be administered. C-reactive protein, interleukin-6, tumor necrosis factor-"c, and other markers of inflammation, endothelial dysfunction, and cellular adhesion will be measured.
New data from this study will provide a unique opportunity to evaluate the relationship of new factors to the presence and severity of retinopathy and to the progression of retinopathy and incidence of other micro- vascular (e.g., diabetic nephropathy) and macrovascular (e.g., lower extremity amputation, myocardial infarction) complications and will provide needed information regarding the associations of retinopathy and visual impairment to self-reported visual-targeted quality of life and depression in persons with long duration of type 1 diabetes. These data will be useful to patients and their physicians involved in the management of diabetes and to public health practitioners designing and delivering preventive care services. Conversely, the new data to be collected in this study may provide insights into the relative protective value of low levels of markers of inflammatory, cell adhesion, and endothelial dysfunction on vascular complications of diabetes mellitus.
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Retinal Vessel Biomarkers for Risk Assessment of Incident Diabetic Complications in the WESDR
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批准号:8833707
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项目类别:
-
资助金额:$99.43万
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财政年份:2014
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负责人:RONALD KLEIN
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依托单位:
Novel Risk Factors for Chronic Kidney Disease
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批准号:7139753
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项目类别:
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资助金额:$38.67万
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财政年份:2006
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负责人:RONALD KLEIN
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依托单位:
Novel Risk Factors for Chronic Kidney Disease
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批准号:7460727
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项目类别:
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资助金额:$9.3万
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财政年份:2006
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负责人:RONALD KLEIN
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依托单位:
Novel Risk Factors for Chronic Kidney Disease
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批准号:7278268
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项目类别:
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资助金额:$32.04万
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财政年份:2006
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负责人:RONALD KLEIN
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依托单位:
Epidemiology of Diabetic Retinopathy
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批准号:6900166
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项目类别:
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资助金额:$82.38万
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财政年份:2005
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负责人:RONALD KLEIN
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依托单位:
Epidemiology of Diabetic Retinopathy
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批准号:7269841
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项目类别:
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资助金额:$38.82万
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财政年份:2005
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负责人:RONALD KLEIN
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依托单位:
Epidemiology of Diabetic Retinopathy
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批准号:7483591
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项目类别:
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资助金额:$39.09万
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财政年份:2005
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负责人:RONALD KLEIN
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依托单位:
Microvascular - Macrovascular Disease in Type 2 Diabetes
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批准号:6927141
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项目类别:
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资助金额:$18.19万
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财政年份:2004
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负责人:RONALD KLEIN
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依托单位:
Microvascular - Macrovascular Disease in Type 2 Diabetes
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批准号:6818990
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项目类别:
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资助金额:$18.19万
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财政年份:2004
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负责人:RONALD KLEIN
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依托单位:
Multi-Ethnic Study of Atherosclerosis-Eye Study
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批准号:6623188
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项目类别:
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资助金额:$42.85万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Multi-Ethnic Study of Atherosclerosis-Eye Study
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批准号:6463902
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项目类别:
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资助金额:$64.01万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Retinal Microvascular Characteristics/Vascular Disorders
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批准号:6658192
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项目类别:
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资助金额:$14.55万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Multi-Ethnic Study of Atherosclerosis-Eye Study
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批准号:6901123
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项目类别:
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资助金额:$26.55万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Multi-Ethnic Study of Atherosclerosis-Eye Study
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批准号:6863428
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项目类别:
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资助金额:$3.8万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Retinal Microvascular Characteristics/Vascular Disorders
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批准号:6455259
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项目类别:
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资助金额:$14.55万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
Multi-Ethnic Study of Atherosclerosis-Eye Study
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批准号:6752049
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项目类别:
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资助金额:$30.26万
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财政年份:2002
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负责人:RONALD KLEIN
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依托单位:
RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
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批准号:6530750
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项目类别:
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资助金额:$7.28万
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财政年份:2001
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负责人:RONALD KLEIN
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依托单位:
RETINAL ARTERIOLAR ABNORMALITIES AND CV MORTALITY
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批准号:6224926
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项目类别:
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资助金额:$18.19万
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财政年份:2001
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负责人:RONALD KLEIN
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依托单位:
CARDIOVASCULAR DISEASE IN TYPE I DIABETES
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批准号:2751754
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项目类别:
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资助金额:$74.49万
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财政年份:1999
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负责人:RONALD KLEIN
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依托单位:
WISCONSIN EPIDEMIOLOGICAL STUDY OF CARDIOVASCULAR DISEAS
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批准号:6498950
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项目类别:
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资助金额:$41.73万
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财政年份:1999
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负责人:RONALD KLEIN
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依托单位:
海外基金