Functional Neuroimaging In Turner Syndrome

描述(由申请人提供)：拟议研究的主要目标 是研究视觉空间加工的神经生物学关联 功能磁共振成像在Turner综合征(TS)中的应用 (功能磁共振成像)。TS是一种具有相同病因的神经发育综合征， 为研究大脑-行为关系提供了一个模型。近期 研究表明，患有TS的个体在 视觉空间信息加工，而不是言语信息加工。 此外，这些特定于领域的视觉空间信息处理 在这方面，缺陷可能是次要的，而不是更核心的工作记忆问题 综合症。尽管认知缺陷一直是 到目前为止，这些缺陷背后的神经回路已经得到了很好的证明 没有被刻画出来。具体地说，还没有发表过功能磁共振成像 关于TS的研究。在目前的项目中，研究人员将使用功能磁共振成像来 检查受试者视觉空间障碍的神经回路 对于TS，特别关注工作记忆。这个项目充分利用 关于TS患者的大样本的可用性，以及 研究人员在进行功能磁共振研究方面的专业知识。具体目标1是 使用功能磁共振成像来识别大脑皮质回路 由语言和非语言工作记忆激活。调查人员将 图15对照受试者和15名使用改良版本的TS患者 由Belger等人开发的工作记忆任务。具体目标2 就是用这个来描述个体的神经认知功能 障碍，特别是探索领域特定缺陷的假说。

DESCRIPTION (provided by applicant): The major goal of the proposed research is to examine the neurobiological correlates of visuospatial processing deficits in Turner syndrome (TS) using functional magnetic resonance imaging (fMRI). TS is a neurodevelopmental syndrome with a homogeneous etiology, and provides a model for the study of brain-behavior relationships. Recent studies have suggested that individuals with TS show significant deficits in visuospatial information processing but not verbal information processing. Furthermore, these domain-specific visuospatial information processing deficits may be secondary to more central working memory problems in this syndrome. Although the cognitive deficits have been well documented to date, the neural circuitry underlying these deficits have not been characterized. Specifically, there have been no published fMRI studies of TS. In the current project the investigators will use fMRI to examine the neural circuits underlying visuospatial impairments in subjects with TS, with a particular focus on working memory. This project capitalizes on the availability of a large sample of individuals with TS, and the expertise of the investigators in conducting fMRI studies. Specific Aim 1 is to use functional magnetic resonance imaging to identify the cortical circuits activated by verbal and nonverbal working memory. The investigators will image 15 control subjects and 15 individuals with TS using a modified version of the working memory tasks developed by Belger et al. Specific Aim 2 is to characterize the neurocognitive functioning of the individuals with this disorder, in particular to explore the hypothesis of domain-specific deficits.