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EFFECTS OF ACIDOSIS ON EXERCISE INDUCED MUSCLE PROTEIN SYNTHESIS

EFFECTS OF ACIDOSIS ON EXERCISE INDUCED MUSCLE PROTEIN SYNTHESIS
酸中毒对运动引起的肌肉蛋白质合成的影响
批准号：
6305556
负责人：
KIRSTEN L. JOHANSEN
金额：
$0.06万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6305556
关键词：
acidosis ammonium chloride biopsy clinical research clinical trial phase I exercise human subject muscle metabolism muscle proteins protein biosynthesis

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中文摘要
翻译
本研究将探讨实验诱导的代谢性酸中毒对肌肉活检样本中蛋白质合成的影响，这些样本在一次抗阻运动前后获得。 每名受试者将接受两次评价。 在一次入院时，他们将接受NH 4CL诱导酸中毒，另一次接受安慰剂。 将在酸中毒和正常条件下比较运动和非运动肢体的肌肉合成率差异，以检验酸中毒将限制对运动的合成代谢反应的假设。
英文摘要
This study will examine the effects of experimentally-induced metabolic acidosis on the synthesis of protein in muscle biopsy samples obtained before and after a bout of resistance exercise. Each subject will be evaluated twice. On one admission they will received NH4CL to induce acidosis, on the other placebo. The difference in muscle synthesis rates in the exercised and non-exercised limb will be compared under acidotic and normal conditions to test the hypothesis that acidosis will limit the anabolic response to exercise.
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