DISORDERS OF LIPID METABOLISM

该方案用于获得血浆脂蛋白和载脂蛋白，以支持Gladstone心血管疾病研究所的许多研究项目。 研究计画包括血浆脂蛋白代谢、动脉硬化及神经细胞功能之相关研究。目前的项目旨在检验载脂蛋白-E的三种主要亚型之间的一级结构差异（氨基酸序列差异）解释了影响脂蛋白代谢中亚型功能的不同三级结构的假设。

This protocol is used to obtain plasma lipoproteins and apolipoproteins to support a number of research projects in the Gladstone Institute of Cardiovascular Disease. The projects include investigations related to plasma lipoprotein metabolism, atherosclerosis, and neural cell function. The current project is designed to test the hypothesis that primary structure differences (amino acid sequence differences) between the three major isoforms of apolipoprotein-E account for different tertiary structures that affect isoform function in lipoprotein metabolism.