Gordon Research Conference on Tetrapyrroles

描述（由申请人提供）：本申请请求支持将于2002年7月14-19日在Salve Regina大学（纽波特，RI）举行的第19届四吡咯化学和生物学戈登研究会议。这个两年一度的跨学科会议促进了基础生物学家，化学家和对四吡咯感兴趣的临床医生之间的合作超过三十年。与蛋白质结合，四吡咯作为生物氧化还原催化剂，用于收集光能，用于氧活化/递送和作为信号分子发挥多种作用。游离四吡咯也是必需营养素（例如，维生素B12），作为基因表达的调节剂（例如，血红素）并已被用作治疗剂（例如，光动力癌症治疗、放射性核素的靶向递送）。由于它们的光动力活性、毒性和亲脂性，四吡咯（例如，卟啉、胆红素）与皮肤、肝脏和大脑的多种病理学有关。由于这些原因，本次会议代表了四吡咯基础和应用研究人员之间交流的重要场所，以及生物医学行业正在开发的新工具和疗法的改进。本申请中要求的资金旨在支持以前没有机会参加这次会议的调查人员。在促进年轻调查员的参与方面作出了特别努力。增加了两个新会议之一，以突出基因组学，蛋白质组学和蛋白质技术的最新发展和未来前景;第二个新会议将重点关注红细胞生成和细胞凋亡的分子调控机制及其与血液和肝脏疾病的关系。将有22名特邀演讲者，一名全体讲师和8名讨论领导者，他们因其科学卓越，最近的创新工作和计划的广度而被选中。其余100名与会者将被挑选出来，以确保来自学术界、医学研究机构和工业界各学科的妇女、族裔和青年科学家的广泛代表性。这个正在进行的戈登会议的优势是其学科的多样性，重点是新的未发表的工作，讨论的时间，非正式的气氛，并禁止传播会议记录。

DESCRIPTION (provided by applicant): This application requests support for the 19th Gordon Research Conference on the Chemistry and Biology of Tetrapyrroles, to be held at Salve Regina University, Newport, RI, from July 14-19, 2002. This biennial interdisciplinary conference has stimulated collaborations between basic biologists, chemists and clinicians interested in Tetrapyrroles for more than three decades. In association with proteins, Tetrapyrroles serve diverse roles as biological redox catalysts, for harvesting of light energy, for oxygen activation/delivery and as signaling molecules. Free Tetrapyrroles are also essential nutrients (e.g., vitamin B12), serve as regulators of gene expression (e.g., hemes) and have been utilized as therapeutic agents (e.g., photodynamic cancer therapy, target delivery of radionuclides). Owing to their photodynamic activity, toxicity and lipophilicity, the accumulation of Tetrapyrroles (e.g., porphyrins, bilirubin) is associated with numerous pathologies of the skin, liver and brain. For these reasons, this conference represents an important venue for exchange between basic and applied researchers on Tetrapyrroles and for refinement of new tools and therapies which are under development by the biomedical industry. Funds requested in this application are targeted to support investigators who have not previously had the opportunity to attend this conference. A special effort has been placed in promoting participation of young investigators. One of two new sessions has been added to highlight recent developments and what the future promises in genomics, proteomics and protein technologies; the second new session will focus on the molecular regulatory mechanisms of erythropoiesis and apoptosis and their implications in relation to blood and liver disorders. There will be 22 invited speakers, a plenary lecturer and 8 discussion leaders, who have been selected for their scientific excellence, recent innovative work and breadth of the program. The remaining 100 conferees will be chosen to ensure a broad representation of women, ethnicity and young scientists from various disciplines in academia, medical research institutions and industry. Strengths of this ongoing Gordon conference are its disciplinary diversity, focus on new unpublished work, time for discussion, informal atmosphere, and ban on dissemination of conference proceeding.