Long-Lasting Effects of Neonatal Pain on Nociception

描述：（由申请人提供）动物未成熟的神经系统 婴儿的可塑性非常强短暂的不适当的感觉 在发展的关键时间窗口期间的投入可能导致永久性的 感官知觉的改变。侵入性和外科手术的影响 在婴儿期关于伤害感受发展的经验已经被 令人惊讶地被忽视了。我们缺乏对 童年的痛苦被人类婴儿 在儿童时期遇到疼痛，通常由侵入性手术引起， 手术和外伤根据以前的研究和我们目前对 即使是成年人的伤害感受系统也是可塑的， 幼年动物的痛苦经历会对 成人疼痛敏感性这些实验的目的是确定 新生大鼠幼仔的炎性损伤永久性地影响其机械 和热敏感性，以确定最大的临界窗口 易感性，并开始表征神经机制， 疼痛敏感性的改变我们的研究结果很可能 影响我们对疼痛发展的基本理解， 婴儿疼痛的管理。

DESCRIPTION: (provided by applicant) The immature nervous systems of animals and infants are exceptionally malleable. Brief periods of inappropriate sensory input during critical time windows of development can lead to permanent alterations in sensory perception. The effects of invasive and surgical experiences during infancy on the development of nociception have been surprisingly neglected. Our lack of understanding about the effects of childhood pain is underscored by the frequency with which human infants encounter pain during childhood, commonly arising from invasive procedures, surgery and trauma. Based on previous research and our current appreciation of how malleable even the adult nociceptive system is, it would be anticipated that painful experiences in young animals would have a permanent effect on adult pain sensitivity. The goal of these experiments is to determine how minor inflammatory injury in newborn rat pups permanently influences their mechanical and thermal sensitivity as adults, to identify the critical window of maximum susceptibility, and to begin to characterize the neural mechanisms that underlie altered pain sensitivity. The results of our studies are likely to impact our basic understanding of pain development and influence the clinical management of pain in infants.