Late Effects of Cancer Treatment

对接受放射治疗和化疗的癌症长期幸存者的研究，使我们对癌变有了重要的认识。我们与医学部合作，扩展了小细胞肺癌后第二种癌症的研究，以评估筛查和随访的几个临床参数。我们也在更新幸存者的数据，以完善风险估计。我们与放射流行病学处合作，开始了一项视网膜母细胞瘤幸存者发展成黑色素瘤的研究。我们正在检查幸存者和他们的一级亲属，以及视网膜母细胞瘤和黑色素瘤患者的一级亲属。视网膜母细胞瘤的治疗信息已经获得，但我们还将获得整个队列的阳光、烟草和酒精暴露信息。死亡率分析表明，视网膜母细胞瘤后肺癌的发病率明显增加，而没有明显的吸烟增加。我们继续在一组儿童时期接受头颈部照射的个体中进行辐射相关神经肿瘤的实地研究。我们计划再增加40名患有头颈部神经肿瘤的队列成员。

Studies of long-term survivors of cancer treated with radiation therapy and chemotherapy have led to important insights into carcinogenesis. In collaboration with the Medicine Branch, we have extended the study of second cancers after small cell lung cancer to evaluate several of the clinical parameters of screening and followup. We are also updating the data for the survivors to refine the risk estimates. In collaboration with the Radiation Epidemiology Branch, we have initiated a study of survivors of retinoblastoma who have developed melanoma. We are examining survivors and their first degree relatives and first degree relatives of individuals with retinoblastoma and melanoma who are deceased. Information on treatment for the retinoblastoma is already available, but we will also obtain sun, tobacco, and alcohol exposure information for the entire cohort. Mortality analyses have indicated that there is a significant excess of lung cancer following retinoblastoma, without any apparent excess smoking. We have continued the field work for the study of radiation-related neural tumors in a cohort of individuals who received head and neck irradiation in childhood. We plan to add up to 40 additional cohort members to the study who have developed head and neck neural tumors.