Effect of laparoscopic gastric banding and angiotensin converting enzyme inhibitor on metabolic myocardial disease

拟议的研究将增加关于药物对肾素-血管紧张素-醛固酮系统的影响以及通过锁孔手术在肥胖和糖尿病引起的心肌僵硬和疤痕组织形成方面大幅减轻体重的新信息。所获得的知识对于深入了解营养过度、高血压、糖尿病引起的心力衰竭的潜在过程以及确定旨在减少未来心力衰竭的策略至关重要。

The proposed research studies will add novel information about the effects of drug acting on Renin-Angiotensin-Aldosterone system and substantial weight reduction by key hole surgery on heart muscle stiffening and scar tissue formation due to obesity and diabetes. The knowledge gained will be essential to gain important insights into the underlying process of heart failure due to over-nutrition, high blood pressure, diabetes and define strategies aimed at reducing future heart failure.