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MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II

MOUSE MODEL--TARGETED GENE KNOCK-OUT OF PROSTAGLANDIN SYNTHASE I AND II
小鼠模型——前列腺素合成酶I和II的靶向基因敲除
批准号：
6432237
负责人：
Robert Langenbach
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6432237
关键词：
adenomatous polyps carcinogen testing chemical carcinogen chemical carcinogenesis colorectal neoplasms cutaneous papilloma disease /disorder model gene targeting genetically modified animals laboratory mouse mutagen testing mutagens neoplasm /cancer genetics nonsteroidal antiinflammatory agent phorbols prostaglandin E prostaglandin endoperoxide synthase toxicology

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中文摘要
翻译
工作总结：在COX基因敲除小鼠中，正在进行一系列项目，以阐明单个环氧合酶(COX)亚型的生理功能。已经产生了COX1和COX2基因缺失的小鼠。这些小鼠，以及只携带一种COX基因的小鼠，正被用来确定单个COX亚型的生理作用，并阐明两种亚型单独或联合作用的方式。缺乏这两种亚型的小鼠在动脉导管未闭出生后不久就会死亡，但其他方面发育正常。
英文摘要
Summary of Work: A series of projects to elucidate the physiological functions of the individual cyclooxygenase (COX) isoforms are ongoing with the COX knockout mice. Mice deficient in both COX1 and COX2 have been produced. These mice, and mice carrying only a single copy of one of the COX genes, are being used to determine the physiological roles of the individual COX isoforms and to elucidate the ways in which the two isoforms act individually or in conjunction. Mice deficient in both isoforms die shortly after birth of patent ductus arteriosus, but are otherwise developmentally normal.
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会议论文
Roles Of Cyclooxygenase-1 And -2 In UV-Induced Skin Canc
Effects Of Deficiency Of COX-1 or COX-2 On Chemically-In
Roles of cyclooxygenase 1 & 2 in UV induced skin cancer
Role of PGE2 Receptors in Mouse Skin Cancer
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