Investigating the molecular mechanism of Rab-A5c action at cell edges - WCUB, AfS ENWW

拟南芥GTP酶RAB-A5c在发育中的植物组织细胞的几何边缘具有独特的定位模式。此外，RAB-A5c对这些组织中的细胞生长和分裂是必不可少的，但其作用机制尚不清楚。本研究将主要通过研究RAB-A5c的相互作用组来探讨RAB-A5c作用的分子机制。我将尝试分析RAB-A5c定位到的细胞边缘隔间的内容物。人们希望这项工作将使人们深入了解这种重要植物蛋白质的基本细胞生物学，将其置于世界级支撑生物科学的中心。我们还预计，对Rab GTP酶在重要作物物种中的功能的任何以下研究可能会产生与粮食安全的翻译相关性。优先领域：世界级支撑生物科学，全球粮食安全

The Arabidopsis GTPase RAB-A5c has a unique localisation pattern at the geometric edges of cells in developing plant tissues. Furthermore, RAB-A5c is essential for cell growth and division in these tissues but the mechanism by which it acts remains unknown. This investigation will focus on probing the molecular mechanism of RAB-A5c action, principally by investigating its interactome. I will attempt to analyse the contents of the cell-edge compartment to which RAB-A5c localises. It is hope that this work will give insights into the fundamental cell biology of this essential plant protein, placing it at the centre of world class underpinning bioscience. We also anticipate that translational relevance to food security may arise from any following investigations of the function of this Rab GTPase in important crop species.Priority Areas: World Class Underpinning Bioscience, Global Food Security