Integrons & antibiotic resistance : modelling of integron evolutionary dynamics - BfH, ENWW

整合子是一种遗传系统，通过其获得和表达被称为基因盒的可移动遗传元件的能力，在细菌中广泛参与抗生素耐药性的传播。虽然这一系统背后的分子机制是众所周知的，但关于盒式磁带获取和表达的潜在动力学，特别是在抗生素施加的选择压力下，仍有许多有待发现。本项目的目的是借助实验数据建立整合子进化动力学的定量数学模型，以更好地了解整合子在抗生素耐药表型传播和表达中的作用。BBSRC优先领域：由于整合子在细菌中获得、表达和传播抗生素耐药基因的主要作用，本项目属于BBSRC对抗微生物耐药性的优先领域。我们的目标是通过一种系统的方法，结合建模和实验数据来解决这个问题。

The integron is a genetic system heavily involved in the spread of antibiotic resistance in bacteria through its ability to acquire and express mobile genetic elements called gene cassettes. While the molecular mechanisms behind this system are well known, a lot remains to be discovered about the underlying dynamics of cassette acquisition and expression, especially when under the selection pressure applied by antibiotics. The aim of this project is to create, with the help of experimental data, a quantitative mathematical model of the integron evolutionary dynamics to better understand its role in the spread and expression of antibiotic resistance phenotypes.BBSRC priorities areas:This project falls into the BBSRC priority of combating microbial resistance due to the major role of the integron in the acquisition, expression and dissemination of antibiotic resistance genes among bacteria. We aim to tackle this problem through a systems approach, combining modelling and experimental data.