Halogen bonding hosts for anion recognition and extraction

在过去的20年里，阴离子的化学识别取得了巨大的进展，部分原因是阴离子在生物、环境和工业过程中的普遍存在。1，2然而，最近才证明，卤素键在结合强度和方向性方面与氢键相当，是用于溶液相阴离子识别的一种强有力的替代非共价相互作用。因此，探索利用卤素键合来修复水的可能性是可取的，因为人类活动对环境，特别是水循环的影响是显著的。目的和目标-将卤素键合基元结合到无环和互锁的有机支架中，用于研究水中的阴离子识别和从水中提取对环境重要的阴离子。尽管卤素键合作为阴离子识别的有效工具在竞争性溶剂介质中被证明是一种有效的工具，但在水中操作的卤素键合系统极其罕见，只有两个以前报道的例子。进一步开发新的卤素键合基序将产生更多关于水介质中这种相互作用的信息，并促进卤素键合在净水中的真实世界应用，这具有全球意义。该项目属于EPSRC的以下研究领域：全球不确定性、与环境变化共存、制造未来、医疗技术和物理科学。与Johnson Matthee合作，卤素键合支架设计将促进卤素键合亲脂受体类似物与二氧化硅或聚合物材料的连接，以生产有毒阴离子的新型萃取剂。

The chemical recognition of anions has progressed enormously in the last 20 years, partially in response to the ubiquity of anions in a vast range of biological, environmental and industrial processes.1,2 However it has only been recently demonstrated that halogen bonding, comparable to hydrogen bonding in terms of its binding strengths and directionality, is a powerful alternative non-covalent interaction for the purposes of solution phase anion recognition. It is therefore desirable to explore the possibility of using halogen bonding for the purposes of water remediation, since the impacts of anthropological activity to the environment, especially the water cycle, are significant.Aims and Objectives - To incorporate halogen bonding motifs into both acyclic and interlocked organic scaffolds for anion recognition investigations in water and extraction of environmentally important anions from aqueous effluent.Despite the demonstrated ability of halogen bonding to perform in competitive solvent media as an effective tool in anion recognition, halogen bonding systems operating in water are extremely rare, with only two previous examples reported. Further exploitation of novel halogen bonding motifs will generate more information on this interaction in aqueous media and facilitate a real world application of halogen bonding to water purification, which is of global significance.This project falls within the following EPSRC research areas: Global Uncertainties, Living With Environmental Change, Manufacturing the future, Healthcare technologies and Physical Sciences.In collaboration with Johnson Matthey the halogen bonding scaffold design will facilitate the attachment of halogen bonding lipophilic receptor analogues to silica or polymer materials to produce novel extractants for toxic anions.