Understanding the structure and function of the DDR1 juxtamembrane region

盘状蛋白结构域受体（DDRs）是细胞外基质蛋白胶原的受体。ddr在发育中发挥重要作用，并促进许多人类疾病的疾病进展。虽然我们对DDR细胞外区域与胶原蛋白之间的相互作用有了详细的了解，但对胶原蛋白结合如何导致细胞内激酶激活知之甚少。我的实验室发现ddr受到细胞内近膜区域的积极调节。该项目将使用生化和结构方法来研究膜旁区域促进DDR激活的机制。

Discoidin domain receptors (DDRs) are receptors for the extracellular matrix protein collagen. The DDRs play important roles in development and contribute to disease progression of a number of human diseases. While we have detailed understanding of the interactions between the DDR extracellular region with collagen, not much is known about how collagen binding results in intracellular kinase activation. My lab has discovered that the DDRs are positively regulated by their intracellular juxtamembrane regions. This project will use biochemical and structural approaches to investigate the mechanisms whereby juxtamembrane regions promote DDR activation.