MRI MEASUREMENT OF RELATIVE CMR02-- VALIDATION USING PET

此资助提案“MRI测量相对CMRO 2：使用PET进行验证”是R 01奖的申请。该项目的目标是：1）开发和验证MR方法，用于动物模型和人类志愿者在不同生理条件下相对局部脑氧代谢率（rCMRO 2）的定量成像; 2）验证神经元调制局灶性脑激活设置中CMRO 2变化与血流动力学之间的关系。 基本假设是，MR测量的多个血流动力学观测值- BOLD信号，CBF和CBV -将使区域和时间的评估相对CMRO 2与正电子发射断层扫描在啮齿动物和人类。这些研究将进一步测试脑生理学的科学假设：CMRO 2和CBF的变化表现出耦合关系，通常与从血液到脑组织的氧气输送的扩散限制模型一致，并且如初步数据所示。在此框架内，我们将测试的基本假设之间的关系MRI信号和潜在的物理和生理，并提供确证的数据MR 1测量相对CMRO 2和CBF。成功完成拟议的研究将建立一个新的工具，用于评估脑功能生理学和序言这些技术的应用到脑病理学。

This grant proposal, "MRI Measurement of Relative CMRO2: Validation using PET", is an application for an R01 award. The goal of the proposed project is to 1) develop and validate MR methods for quantitative imaging of the relative regional cerebral metabolic rate of oxygen utilization (rCMRO2) under different physiological conditions in animal models and in human volunteers, and 2) validate the relationship between changes in CMRO2 and hemodynamics in the setting of neuronally-modulated focal brain activation. The fundamental hypothesis is that MR measurements of multiple hemodynamic observables - BOLD signal, CBF, and CBV - will enable regional and temporal assessment of relative CMRO2 in agreement with positron emission tomography in rodents and humans. These studies will further test a scientific hypothesis of cerebral physiology: that changes in CMRO2 and CBF exhibit a coupling relationship in general accordance with diffusion-limited models of oxygen delivery from the blood to brain tissue, and as demonstrated by preliminary data. Within this framework we will test the basic assumptions about the relationship between MRI signals and the underlying physics and physiology and provide corroborative data for MR1 measurements of relative CMRO2 and CBF. Successful completion of the proposed studies will establish, a new tool for assessment of cerebral functional physiology and preface the application of these techniques to cerebral pathology.