NIGMS MARC PREDOCTORAL FELLOWSHIP

我对研究神经退行性疾病感兴趣， 阿尔茨海默氏病使用神经遗传学，细胞生物学相结合 和分子生物学。 今年夏天在剑桥大学，我 学会了做一种荧光原位杂交， 染色体彩绘 我用这种技术来识别 精神分裂症患者的染色体易位 迟钝 我想把染色体绘画应用到学习中去 染色体畸变发生在患有 老年痴呆症或中风。 去年夏天，在圣乔治医院医学院， 伦敦大学，我学会了使用流动透析研究人工 膜在宏观层面上。 我还观察了贴片的使用 夹以研究单个孔隙。 我了解到， 钙通道与各种神经系统疾病有关。 所以我 我想用流动透析和膜片钳来研究钙 渠道 我在其他机构读本科时的研究工作 让我有机会用技术研究各种蛋白质， 细胞和分子生物学，如细胞克隆，细胞培养，高 高压液相色谱法，气相色谱-质谱法 及DNA测序 我想继续学习其他细胞， 分子生物学技术 我希望在一个 正常人和正常人的神经元蛋白质的比较研究 患有阿尔茨海默病或中风的个体。

I am interested in studying neurodegenerative disorders such as Alzheimer's disease using a combination of neurogenetics, cell biology and molecular biology. This summer at Cambridge University, I learned to do a type of fluorescence in situ hybridization called chromosome painting. I used this technique to identify the origin of chromosomal translocations in patients suffering from mental retardation. I would like to apply chromosomes painting to study chromosomal aberrations occurring in patients suffering from Alzheimer's disease or stroke. Last summer at St. George's Hospital Medical School of the University of London, I learned to use flow dialysis to study artificial membranes at the macroscopic level. I also observed the use of patch clamp to study single pores. I have learned that the malfunction of calcium channels is involved in various neurological diseases. Thus, I would like to use flow dialysis and patch clamp to study calcium channels. My research work as an undergraduate at other institutions has afforded me the opportunity to study various proteins using techniques of cell and molecular biology such as cell cloning, cell culture, high presser liquid chromatography, gas chromatography-mass spectrometry and DNA sequencing. I would like to continue to learn other cell and molecular biology techniques. I hope to use such techniques in a comparative study of neuronal proteins of normal individuals and individuals suffering from Alzheimer's disease or stroke.