Efferent Connections of the Hippocampal Field CA1

拟建项目的长期目标是阐明海马体领域CAI的投影组织。为了实现这一目标，在大鼠中提出了三组特定的实验：1)使用顺行示踪剂PHAL，详细研究从野CAI到外侧间隔复合体、到耻骨下和到鼻内区的轴突投影；2)利用逆行示踪剂氟金对现场CAI的神经输入研究；3)海马中隔颞轴突起的地形组织分析。更好地理解ca1领域所涉及的回路和这些投射的组织将有助于更好地理解海马体作为一个整体，以及它如何与其他系统相互作用以控制目标导向的行为。这种理解最终将导致在治疗与衰老、疾病和创伤有关的某些疾病方面取得突破。

The long-range goal of the proposed project is to clarify the organization of projections from field CAI of the hippocampus. To accomplish this goal, three specific groups of experiments in the rat are proposed: 1) A detailed study of axonal projections from field CAI to the lateral septal complex, to the subiculum, and to the entorhinal area using the anterograde tracer, PHAL; 2) A study of neural inputs to field CAI using the retrograde tracer, fluorogold; 3) An analysis of the topographic organization of projections along the septotemporal axis of the hippocampus. A better understanding of the circuitry in which field CA 1 is involved and the organization of these projections will lead to a better understanding of the hippocampus as a whole and how it interacts with other systems to control goal-directed behavior. Such understanding will eventually lead to breakthroughs in the treatment of certain disorders related to aging, diseases, and trauma.