CARDIOVASOLOGY

（申请人？s摘要） 这一更新申请代表了26至30年的资金请求 我们的培训补助金名为“心血管学”。该培训计划已 在为独立的研究生涯做准备方面非常成功 在心血管医学和生物学方面，我们目前的应用是 其特点是越来越注重翻译研究， 组建一支由资深调查人员组成的跨学科团队。拟议 培训计划的重点是心力衰竭和缺血性综合征 心脏病选择这两个相互关联的主题是基于 目前的专业知识，这两种疾病所发挥的核心作用， 美国人群中的实体，更具体地说， 马约诊所关注心力衰竭的另一个理由是， 缺血性心脏病是这些复杂的综合征， 多种细胞类型，需要多学科的方法，因此 提供一个强大的机制，汇集教师，并提供多样化的 为学员提供研究机会。学院由一个合作的 基础科学家、医学科学家、临床科学家和 调查人员和人口科学家， 指导。此外，我们设计了我们的竞争性更新， 与NHLBI“SPARKS”报告的建议平行，因此我们 教师结合遗传学，细胞生物学，研究培训，在 组织和整体动物水平与人类生理学和种群科学。 这是我们的竞争性更新的目标，培养人才在新的 生物学和强调创新的方法，将促进 心血管疾病病理生理学的理解 导致新的诊断和治疗的疾病。以我们现在的 竞争性更新，我们提出了一个充满活力和高度人才的多学科 一组具有记录在案的指导技能的资深调查员， 记录培训计划教师中代表的当前技术 包括分子遗传学、药物基因组学、功能基因组学 流行病学和结果研究，基因治疗和移植生物学 它补充了传统的内科，儿科， 外科学、药理学、生理学、生物化学和分子生物学。因此，在本发明中， 学员们接触到多种技术，这些技术是围绕 心力衰竭和缺血性心脏病的翻译主题。基本 这一努力仍然是毫无保留地致力于受训人员的多样性， 教师除了承诺卓越。我们相信我们的 竞争性更新制定了一项战略，以继续这一传统， 在心血管生物学和医学方面的研究培训方面取得了卓越的成绩。

(Applicant?s Abstract) This renewal application represents a request for funding for years 26 to 30 of our training grant entitled Cardiovasology. This training program has been highly successful in preparing individuals for an independent research career in cardiovascular medicine and biology, and our current application is characterized by an increasing focus upon translational research that brings together an interdisciplinary team of established investigators. The proposed training program is focused upon the syndromes of heart failure and ischemic heart disease. These two interrelated themes were chosen based upon the current expertise of the faculty, the central role played by these two disease entities in the US population and more specifically the patient population at the Mayo Clinic. An additional rationale for focusing upon heart failure and ischemic heart disease is that these are complex syndromes which involve multiple cell types, require multidisciplinary approaches and therefore provide a powerful mechanism to bring together the faculty and provide diverse research opportunities for trainees. The faculty consists of a collaborative and innovative team of basic scientists, physician-scientists, clinical investigators and population scientists with established track records in mentoring. Moreover, we have designed our competitive renewal to be in parallel with recommendations of the NHLBI "SPARKS" report and therefore our faculty incorporates genetics, cellular biology, research training at the tissue and whole animal level with human physiology and population sciences. It is the goal of our competitive renewal to train talented individuals in new biology and an emphasis upon innovative methodologies that will facilitate translation in the understanding of the pathophysiology of cardiovascular disease leading to novel diagnostics and therapeutics. With our current competitive renewal we propose a vibrant and highly talented multidisciplinary group of established investigators with documented mentoring skills and records. Current technologies represented in the training program faculty include molecular genetics, pharmacogenomics, functional genomics, epidemiology and outcomes research, gene therapy and transplantation biology which complement traditional departments of internal medicine, pediatrics, surgery, pharmacology, physiology, biochemistry and molecular biology. Thus, trainees are exposed to multiple technologies that are organized around the translational themes of heart failure and ischemic heart disease. Fundamental to this effort remains an unreserved commitment to diversity of trainees and faculty in addition to the commitment excellence. We believe that our competitive renewal lays down a strategy to continue this tradition of excellence in research training in cardiovascular biology and medicine.