MACROMOLECULAR MODELS FOR CELL BIOLOGY CD ROM TEACHING TOOL

我正在制作一个CD-ROM，它利用了 酵母和科学史的背景下，细胞的主题 生物学包括生物化学、遗传学和分子生物学。 的 该项目面向初中及以上的学生。 困难的生物学概念是通过沉重的 使用图形，动画和特别令人兴奋的视觉数据 由世界各地的研究实验室产生。 MidasPlus软件和 加州大学旧金山分校计算机图形实验室的设施使我能够 实验并创造出许多吸引人的多肽和核酸 酸图像与一致的图形处理和空间 方向。 我还建立了一个三维代谢物模型库 以同样的方式呈现。 我最近专注于一个 动画的酵母生命周期，将作为主菜单， 访问科学数据和附带的动画。 我也是 制作生物过程的卡通模型， 大分子结构数据 我刚刚完成了一个序列， 显示了受体介导的G蛋白信号，第二信使 系统和激酶级联起作用。 GTP，GDP， ATP，ADP等被用来代替字母，许多漫画 可以点击链接到PDB结构数据的图形输出。 沿着图形、关于蛋白质数据的信息和 提供了酵母基因座的位置。 这种视觉 信息管理不仅使学生的学习更容易， 也解决了一些交叉引用超载的问题， 和基因组数据库正在努力解决的问题。

I am producing a CD-ROM that utilizes both the model system of yeast and the history of science to contextualize the subject of cell biology including biochemistry, genetics and molecular biology. The program is geared for students from junior high school and up. Difficult biological concepts are made accessible through the heavy use of graphics, animation and especially exciting visual data generated by research labs around the world. MidasPlus software and the facilities of the UCSF Computer Graphics Lab have allowed me to experiment with, and create many appealing polypeptide and nucleic acid images with consistent graphic treatment and spatial orientations. I also have made a library of 3-D metabolite models rendered in the same manner. I have recently concentrated on an animation of the yeast life cycle that will serve as the main menu for access to scientific data and accompanying animations. I am also making cartoon models of biological processes that link to the macromolecular structural data. I have just finished a sequence that shows how receptor mediated G-protein signaling, second messenger systems and kinase cascades work. Color coded 3-D models of GTP, GDP, ATP, ADP etc. are used instead of letters, and many of the cartoons can be clicked to link to graphic output of PDB structural data. Along with the graphics, information about the protein data and the location of yeast gene loci are provided. This type of visual information management not only makes learning for students easier it also solves some of the cross-reference overload problems that protein and genome databases are struggling with.