Enhancing MRI assisted neuro-stimulation electrode placement for paediatric subjects

该项目的目的是1)开发和测试成像脑深部核的方法，这些方法必须精确定位神经刺激电极的位置；2)设计、模拟和测试安全插入电极的方法，并使用MRI验证其精确放置。建议方法的目标人群是儿科-儿童从神经刺激中获益最多，因为与老年人相比，他们的大脑具有更大的可塑性，但他们也是最具挑战性的对象，因为糟糕的程序和次优治疗而损失最大。

The aim of the project is to 1) develop and test methods to image deep brain nuclei that must be precisely targeted for placement of neuro-stimulation electrodes and 2) to devise, simulate and test methods to safely insert electrodes and verify their precise placement using MRI. The target population for the proposal methods is paediatric -children have the most to gain from neuro-stimulation owing to the greater plasticity of their brains compared to older subjects, but they are also most challenging subjects with the most to lose through poor procedures and sub-optimal treatment.