Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI
批准号:
10493089
负责人:
Gregory John Metzger
金额:
$56.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-23 至 2026-08-31
关键词:
AddressAdoptionAffectAnatomyBiological MarkersBiopsyBlood TestsCancer DetectionCancer EtiologyCessation of lifeClinicClinicalClinical TrialsCollaborationsComputer softwareDataData SetDetectionDevelopmentDevicesDiagnosisDiagnostic ProcedureDigital Rectal ExaminationDiseaseDisease ManagementEnsureEnvironmentEvaluationFutureGoalsHealthcare SystemsHistopathologyImage AnalysisImaging PhantomsImpotenceIncontinenceInvestigationLesionLifeLocationMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of prostateManufacturer NameMapsMeasuresMethodsModelingOutcomePatientsPerformancePhysiciansPositioning AttributePrevalenceProceduresProcessProstateProstate-Specific AntigenProtocols documentationQuality of lifeQuantitative EvaluationsRadiology SpecialtyReportingReproducibilitySamplingScreening for Prostate CancerSensitivity and SpecificitySiteSystemTechnologyTrainingTranslatingTranslationsTransrectal UltrasoundValidationVendoranalysis pipelinebaseblindclinical applicationclinical centerclinical translationcomputer aided detectioncomputer-assisted diagnosticscostdesigndetection platformdiagnostic platformdiagnostic toolexperienceimage guidedimaging modalityimaging systemimprovedindustry partnerinterestmalemennew technologynon-invasive monitornovelpredictive modelingprostate lesionsquantitative imagingradiologistrisk stratificationserum PSAtargeted imagingtooltumor specificityvalidation studies
中文摘要
尽管前列腺癌的流行,目前可用的工具来控制疾病继续
英文摘要
Despite the prevalence of prostate cancer, the current tools available to manage the disease continues to
leave physicians and their patients in a position to overdiagnose and overtreat. The confidence to pursue more
conservative approaches like active surveillance are limited, as biopsy is known to underestimate the grade
and extent of disease, both of which are important for risk stratification. Targeted biopsies, by means of MRI-
guidance, are becoming the preferred way to ensure the most aggressive appearing lesions are sampled in the
hopes of avoiding some of the issues with standard biopsy approaches. These targeted biopsies make use of
multi-parametric MRI (mpMRI) which includes both anatomical and functional information that are
complimentary and together increase the sensitivity and specificity for cancer detection. However, the ability to
effectively use mpMRI requires specialized training while the standards for properly using the multiple MRI
datasets are still being developed. To address this issue, we have developed an alternative method that would
provide a quantitative, user-independent, summary of the mpMRI data (qMRI) to visually “map” disease and
assess its aggressiveness. Using quantitative MRI, a Composite Biomarker Score (CBS) map is generated,
with a demonstrated increase in sensitivity and specificity for tumor detection compared to any single qMRI
parameter. Our primary goal is to integrate this predictive qMRI model into a computer-aided diagnostic (CAD)
system (referred to as CBS-CAD) to improve the use of mpMRI in PCa management. Employing quantitative
MRI (qMRI) can address the issues of a qualitative image analysis if the major roadblocks to its adoption can
be overcome. To address the roadblocks and implement the CBS-CAD system we will pursue the following
specific aims: 1) develop an analysis pipeline to evaluate qMRI performance and translate CBS-CAD methods,
2) perform a multi-vendor, multi-site quantitative imaging technical performance evaluation and 3) perform a
multi-center clinical validation study assessing CBS-CAD performance. Our expected outcome of this
academic-industry partnership will be the integration of several novel technologies into a comprehensive CAD
system consisting of a phantom and automated software for 1) qMRI system validation and 2) clinical
translation of novel models for detecting cancer and assessing aggressiveness.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
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批准号:10391523
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项目类别:
-
资助金额:$61.83万
-
财政年份:2021
-
负责人:Gregory John Metzger
-
依托单位:
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
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批准号:10533352
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项目类别:
-
资助金额:$60.45万
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财政年份:2021
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负责人:Gregory John Metzger
-
依托单位:
Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI
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批准号:10705180
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项目类别:
-
资助金额:$61.75万
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财政年份:2021
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负责人:Gregory John Metzger
-
依托单位:
Development of Enabling Technologies for Clinical Ultrahigh Field Body MRI
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批准号:10210905
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项目类别:
-
资助金额:$60.95万
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财政年份:2021
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负责人:Gregory John Metzger
-
依托单位:
Technology to Realize the Full Potential of UHF MRI (Supplement)
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批准号:10285102
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项目类别:
-
资助金额:$37.72万
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财政年份:2019
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负责人:Gregory John Metzger
-
依托单位:
Technology to Realize the Full Potential of UHF MRI
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批准号:10549850
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项目类别:
-
资助金额:$118.94万
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财政年份:2019
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负责人:Gregory John Metzger
-
依托单位:
Technology to Realize the Full Potential of UHF MRI
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批准号:10376730
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项目类别:
-
资助金额:$120.32万
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财政年份:2019
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负责人:Gregory John Metzger
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依托单位:
TRD2 - Ultrahigh Field Molecular Imaging and Spectroscopy
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批准号:10376733
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项目类别:
-
资助金额:$31.63万
-
财政年份:2019
-
负责人:Gregory John Metzger
-
依托单位:
TRD2 - Ultrahigh Field Molecular Imaging and Spectroscopy
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批准号:10549854
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项目类别:
-
资助金额:$31.63万
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财政年份:2019
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负责人:Gregory John Metzger
-
依托单位:
Development of an Optimal MRI Platform for Prostate Investigations at 7 Tesla
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批准号:8234736
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项目类别:
-
资助金额:$54.43万
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财政年份:2012
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负责人:Gregory John Metzger
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依托单位:
Development of an Optimal MRI Platform for Prostate Investigations at 7 Tesla
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批准号:8535681
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项目类别:
-
资助金额:$25.09万
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财政年份:2012
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负责人:Gregory John Metzger
-
依托单位:
QUANTITATIVE SPECTROSCOPIC AND ANATOMIC PROSTATE IMAGING AT 7 TESLA
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批准号:8362845
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项目类别:
-
资助金额:$3.03万
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财政年份:2011
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负责人:Gregory John Metzger
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依托单位:
MULTI-PARAMETRIC MRI DETERMINATION OF PROSTATE CANCER AGGRESSIVENESS AND EXTENT
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批准号:8362844
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项目类别:
-
资助金额:$3.03万
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财政年份:2011
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负责人:Gregory John Metzger
-
依托单位:
QUANTITATIVE SPECTROSCOPIC AND ANATOMIC PROSTATE IMAGING AT 7 TESLA
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批准号:8170450
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项目类别:
-
资助金额:$2.57万
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财政年份:2010
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负责人:Gregory John Metzger
-
依托单位:
MULTI-PARAMETRIC MRI DETERMINATION OF PROSTATE CANCER AGGRESSIVENESS AND EXTENT
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批准号:8170449
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项目类别:
-
资助金额:$2.57万
-
财政年份:2010
-
负责人:Gregory John Metzger
-
依托单位:
QUANTITATIVE SPECTROSCOPIC AND ANATOMIC PROSTATE IMAGING AT 7 TESLA
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批准号:7954985
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项目类别:
-
资助金额:$2.57万
-
财政年份:2009
-
负责人:Gregory John Metzger
-
依托单位:
MULTI-PARAMETRIC MRI DETERMINATION OF PROSTATE CANCER AGGRESSIVENESS AND EXTENT
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批准号:7954984
-
项目类别:
-
资助金额:$2.57万
-
财政年份:2009
-
负责人:Gregory John Metzger
-
依托单位:
Multi-parametric MRI Determination of Prostate Cancer Aggressiveness and Extent
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批准号:7847989
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项目类别:
-
资助金额:$5.04万
-
财政年份:2009
-
负责人:Gregory John Metzger
-
依托单位:
DIAGNOSTIC PROSTATE MAGNETIC RESONANCE IMAGING AT 3 TESLA WITH AN ENDORECTAL COI
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批准号:7951698
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项目类别:
-
资助金额:$0.18万
-
财政年份:2008
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负责人:Gregory John Metzger
-
依托单位:
Multi-parametric MRI Determination of Prostate Cancer Aggressiveness and Extent
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批准号:8228100
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项目类别:
-
资助金额:$30.39万
-
财政年份:2008
-
负责人:Gregory John Metzger
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依托单位:
海外基金