Computer Aided Diagnostic System for Prostate Cancer Detection Using Quantitative Multiparametric MRI

使用定量多参数 MRI 检测前列腺癌的计算机辅助诊断系统

• 批准号: 10493089
• 负责人: Gregory John Metzger
• 金额: $ 56.93万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493089
• 关键词: Address; Adoption; Affect; Anatomy; Biological Markers; Biopsy; Blood Tests; Cancer Detection; Cancer Etiology; Cessation of life; Clinic; Clinical; Clinical Trials; Collaborations; Computer software; Data; Data Set; Detection; Development; Devices; Diagnosis; Diagnostic Procedure; Digital Rectal Examination; Disease; Disease Management; Ensure; Environment; Evaluation; Future; Goals; Healthcare Systems; Histopathology; Image Analysis; Imaging Phantoms; Impotence; Incontinence; Investigation; Lesion; Life; Location; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of prostate; Manufacturer Name; Maps; Measures; Methods; Modeling; Outcome; Patients; Performance; Physicians; Positioning Attribute; Prevalence; Procedures; Process; Prostate; Prostate-Specific Antigen; Protocols documentation; Quality of life; Quantitative Evaluations; Radiology Specialty; Reporting; Reproducibility; Sampling; Screening for Prostate Cancer; Sensitivity and Specificity; Site; System; Technology; Training; Translating; Translations; Transrectal Ultrasound; Validation; Vendor; analysis pipeline; base; blind; clinical application; clinical center; clinical translation; computer aided detection; computer-assisted diagnostics; cost; design; detection platform; diagnostic platform; diagnostic tool; experience; image guided; imaging modality; imaging system; improved; industry partner; interest; male; men; new technology; non-invasive monitor; novel; predictive modeling; prostate lesions; quantitative imaging; radiologist; risk stratification; serum PSA; targeted imaging; tool; tumor specificity; validation studies

Despite the prevalence of prostate cancer, the current tools available to manage the disease continues to leave physicians and their patients in a position to overdiagnose and overtreat. The confidence to pursue more conservative approaches like active surveillance are limited, as biopsy is known to underestimate the grade and extent of disease, both of which are important for risk stratification. Targeted biopsies, by means of MRI- guidance, are becoming the preferred way to ensure the most aggressive appearing lesions are sampled in the hopes of avoiding some of the issues with standard biopsy approaches. These targeted biopsies make use of multi-parametric MRI (mpMRI) which includes both anatomical and functional information that are complimentary and together increase the sensitivity and specificity for cancer detection. However, the ability to effectively use mpMRI requires specialized training while the standards for properly using the multiple MRI datasets are still being developed. To address this issue, we have developed an alternative method that would provide a quantitative, user-independent, summary of the mpMRI data (qMRI) to visually “map” disease and assess its aggressiveness. Using quantitative MRI, a Composite Biomarker Score (CBS) map is generated, with a demonstrated increase in sensitivity and specificity for tumor detection compared to any single qMRI parameter. Our primary goal is to integrate this predictive qMRI model into a computer-aided diagnostic (CAD) system (referred to as CBS-CAD) to improve the use of mpMRI in PCa management. Employing quantitative MRI (qMRI) can address the issues of a qualitative image analysis if the major roadblocks to its adoption can be overcome. To address the roadblocks and implement the CBS-CAD system we will pursue the following specific aims: 1) develop an analysis pipeline to evaluate qMRI performance and translate CBS-CAD methods, 2) perform a multi-vendor, multi-site quantitative imaging technical performance evaluation and 3) perform a multi-center clinical validation study assessing CBS-CAD performance. Our expected outcome of this academic-industry partnership will be the integration of several novel technologies into a comprehensive CAD system consisting of a phantom and automated software for 1) qMRI system validation and 2) clinical translation of novel models for detecting cancer and assessing aggressiveness.

尽管前列腺癌的流行，目前可用的工具来控制疾病继续