MENTAL RETARDATION RESEARCH CENTER

此申请是为了继续支持加州大学洛杉矶分校智力迟钝研究中心的行政和研究核心。MRRC最早成立于1969年，与儿童精神病学一起在神经精神病学研究所的四层楼里办公。这个MRRC提供了一个全面的多学科领域的智力迟钝和发育障碍（MRDD）。中心调查人员开展的研究调查涉及国家儿童健康与人类发展研究所（NICHD）为MRDD研究中心发布的当前RFA中列出的大多数MRDD研究重点。该中心的长期目标是发现预防智障的方法，并改善智障人士和其他发育障碍者的生活质量。为了实现这一目标，已经组织了五个多学科的研究小组：临床研究，分子和发育神经科学，神经生物化学和分子遗传学，系统神经科学和社会行为研究。通过研究人员之间的跨学科互动，促进卓越的研究和创新。设有一个行政中心和八个研究中心：(1)分子生物学，(2)细胞生物学，(3)神经细胞学和细胞成像，(4)动物维护和评估，(5)野外工作培训和结果，(6)数据管理和分析，(7)微型计算机和/媒体图形学，(8)技术服务。该中心的基本范围和使命是阐明MRDD发病机制的分子、细胞和行为机制，并将这些基础知识转化为新的诊断、预防和治疗方法，最终应用于临床护理。该中心的功能是通过促进研究人员之间的互动，提供一个促进加州大学洛杉矶分校精神发育迟滞研究的最高水平的环境，并提供免费的尖端和高效的核心服务。中心高度重视支持有才华的年轻研究人员，并在与中心目标相关的各个学科培养博士后和博士后。

This application is for continued support of the administrative and research cores of the UCLA Mental Retardation Research Center. This MRRC was first established in 1969 and housed with Child Psychiatry in a four floors addition to the Neuropsychiatric Institute. This MRRC provides a comprehensive multi-disciplinary in the field of mental retardation and developmental disabilities (MRDD). The research investigations carried out by the Center Investigators address most of the MRDD research priorities listed in the current RFA issued by National Institute of Child Health and Human Development (NICHD) for MRDD Research Centers. The long-term goals of the Center are to discover ways to prevent mental retardation and improve the quality of life for mentally retarded and other developmentally disabled individuals. To accomplish this, five multi- disciplinary research groups have been organized: Clinical Research, Molecular and Developmental Neuroscience Neurobiochemistry and Molecular Genetics, Systems Neuroscience and Socio-behavioral Research. To foster research excellence and innovation through inter- disciplinary interactions among investigators. An Administrative Core and eight research cores have been organized: (1) Molecular Biology, (2) Cell Biology, (3) Neurocytology and Cellular Imaging, (4) Animal Maintenance and Assessment, (5) Field Work Training and Outcome, (6) Data Management and Analysis, (7) Microcomputers and/Media Graphics and (8) Technical Services. The essential scope and mission of the Center are to elucidate the molecular, cellular and behavioral mechanisms underlying the pathogenesis of MRDD and to translate this fundamental knowledge into novel diagnostic, preventive and therapeutic approach which ultimately an be applied to clinical care. The function of the Center is to provide an environment promoting the highest level of research in mental retardation at UCLA by fostering interaction among investigators and providing free access to cutting edge and efficient core services. The Center assigns high priority to the support of talented young investigators and the training of pre- and post-doctoral fellows in a variety of disciplines related to its goals.