INTEGRATIVE PROGRAM IN CNS PATHOPHYSIOLOGY RESEARCH

这是一份机构发展奖（IdeA）的申请，目的是在新墨西哥州大学（UNM）建立一个生物医学研究卓越中心（COBRE），以利用神经影像学为重点的综合方法开展我们在CNS损伤和病理生理学方面的研究。一个目标是加强我们现有的独特的神经影像设施，使他们成为一个国家的最先进的中心，在大脑研究中应用功能性神经影像技术。UNM在过去的十年中在神经成像领域发展了独特的利基，在许多领域具有优势，包括脑磁图（MEG），磁共振波谱（MRS）和最佳成像。我们还在建设一个电子顺磁共振（EPR）设施的过程中，在体内制剂的自由基的非侵入性测量。为该COBRE的核心要求的四件主要设备将大大加强我们的中心，使我们能够在国家一级完成神经成像应用的各个领域。这包括升级现有的4.7T MR扫描仪和用于动物研究的体内EPR光谱仪，以及光电二极管阵列和双光子激光扫描显微镜，用于使用体外和体内制剂进行细胞最佳成像研究。我们的第二个目标是利用这种研究环境来提高我们教师的生产力和研究质量，特别是初级教师，这样我们就可以增加定期个人NIH补助金（R01）水平的资助研究人员的数量。在UNM，有一群成功的高级研究人员，他们定期获得NIH补助金（RO1）。在UNM有一组高级研究人员在中枢神经系统损伤和病理生理学领域的积极RO1级资金，重点是神经影像学，他们可以建立一个合作研究团队，为促进教师发展创造一个令人兴奋和刺激的环境。在过去的十年中，我们机构活跃的调查人员数量的增加使COBRE成为教师发展的理想工具。我们已经确定了四个有前途的初级教师在中枢神经系统损伤和病理生理学领域的工作，谁可以直接得到帮助，从这个IdeA赠款的支持，成为独立的科学家从R01级资金。COBRE主任和我们团队的高级调查员将担任导师。这些指导研究人员提出的研究是多学科和综合性的，旨在对每种类型的病理生理学进行有用的系统纵向表征，并为脑损伤和恢复的可能机制提供新的见解。为了帮助创造一个刺激的研究环境，我们建议发起一个正式的神经病理生理学系列研讨会，每年组织一个小型专题讨论会，及时的主题，并管理一个访问科学家计划。我们还成立了一个国家咨询委员会，由我们领域的杰出科学家组成，他们可以指导我们开发COBRE，根据我们的导师计划，将监测初级教师在科学工作中的进展。

This is an application for the Institutional Development Award (IdeA) to establish a Center for Biomedical Research Excellence (COBRE) at the University of New Mexico (UNM) for carrying our research in CNS injury and pathophysiology using an integrative approach with a neuroimaging focus. One goal is to strengthen our existing unique neuroimaging facilities so that they become integrated into a state-of-the- art Center for applying functional neuroimaging techniques in brain research. UNM has developed a unique niche in neuroimaging over the past ten years with strengths in a number of areas including Magnetoencephalography (MEG), Magnetic Resonance Spectroscopy (MRS), and Optimal Imaging. We are also in the process of constructing an Electron Paramagnetic Resonance (EPR) facility for non-invasive measurements of free radicals in in vivo preparations. Four pieces of major equipment requested for the core of this COBRE would substantially strengthen our Center, enabling us to complete at the national level in various areas of neuroimaging applications. This includes the upgrades of an existing 4.7T MR scanner and in vivo EPR spectrometer for animal studies, and a photodiode array and a two-photon laser scanning microscope for cellular optimal imaging studies using in vitro and in vivo preparations. Our second goal is to utilize this research environment for increasing the productivity and quality of research of our faculty, especially the junior faculty members, so that we can increase the number of funded investigators at the regular individual NIH grant (R01) level. At UNM there is a group of successful senior investigators with active regular individual NIH grant (RO1) level. At UNM there is a group of senior investigators with active RO1-level funding in the area of CNS injury and pathophysiology with a neuroimaging focus who can establish a collaborative research team that can service to create an exciting and stimulating environment for fostering faculty development. The increase in the number of active investigators at our institution over the past decade makes the COBRE an ideal vehicle for faculty development. We have identified four promising junior faculty members working in the area of CNS injury and pathophysiology who can be directly helped with support from this IdeA grant to become independent scientists from R01- level funding. The COBRE Director and the senior investigator our team will serve as the mentors. The proposed research by these mentored investigators is multi-disciplinary and integrative, designed to produce a useful systematic longitudinal characterization of each type of pathophysiology and to provide new insights into the possible mechanisms of brain injury and recovery. To help create a stimulating research milieu, we propose to initiate a formal seminar series on neuro- pathophysiology, to annually organize a mini-symposium on timely thematic topics, and to administer a visiting scientist program. We have also formed a national advisory committee consisting of prominent scientists in our field who can guide us in the development of our COBRE, The progress of the junior faculty members in their scientific work will be monitored according to our mentorship program.