Effects of exercise and lifestyle management on reproductive function in overweight women with polycystic ovary syndrome

多囊卵巢综合征（PCOS）是一种复杂的疾病，存在于5-10%的育龄妇女中。它与肥胖、月经失调和不孕症以及代谢状况如血清胰岛素增加、高胆固醇、糖尿病和心脏病有关。生活方式的干预，旨在减少肥胖和胰岛素抵抗，其中包括饮食减肥和体育活动，主张管理PCOS。然而，虽然研究表明通过饮食减肥可以改善许多症状，但缺乏研究评估体育锻炼在管理这种情况中的综合作用。此外，没有研究检查应该进行的最佳运动形式，以实现长期的生殖健康和代谢健康，因此缺乏PCOS患者的循证运动指南。我们计划进行一项临床研究，以调查PCOS患者的运动与饮食减肥相结合是否为改善月经功能，生育能力和代谢健康提供了任何额外的好处，而不仅仅是使用饮食限制。我们还将评估，当结合饮食限制时，结合耐力和阻力运动的身体活动计划是否比更常见的耐力运动处方提供更大的益处。这些信息将用于协助制定有效管理PCOS患者生殖功能障碍的指南。

Polycystic ovary syndrome (PCOS) is a complex disorder present in 5-10% of women of reproductive age. It is associated with obesity, increased menstrual dysfunction and infertility and metabolic conditions such as increased serum insulin, high cholesterol, diabetes and heart disease. Lifestyle interventions aimed at reducing obesity and insulin resistance, which include dietary weight loss and physical activity, are advocated for the management of PCOS. However, while research indicates that weight loss through diet improves many symptoms, there is a paucity of research evaluating the combined role of physical exercise in managing this condition. In addition, there is no research examining the optimal form of exercise that should be undertaken to achieve long-term reproductive fitness and metabolic health and consequently there is a lack of evidence-based exercise guidelines for patients with PCOS. We plan to perform a clinical study to investigate whether combining exercise with weight loss by diet in patients with PCOS provides any additional benefit for improving menstrual function, fertility and metabolic health beyond those that can be achieved using dietary restriction alone. We will also assess whether, when combined with dietary restriction, a program of physical activity incorporating both endurance and resistance exercise provides a greater benefit than the more common prescription of endurance exercise alone. This information will be used to assist in the development of guidelines for the effective management of reproductive dysfunction in patients with PCOS.