Antimicrobial activity and formulation of propolis extracts

蜜蜂是一种群居昆虫，它们离开蜂箱并在蜂箱中工作。为了保护自己免受细菌、真菌和其他微生物等外部敌人的伤害，他们用蜂胶密封蜂巢，蜂胶是蜜蜂自己产生的。蜂胶除了具有用作密封材料的树脂特性外，还具有所需的所有抗菌和抗菌特性。此外，蜂胶还可以作为抗氧化剂，因为蜂巢可以利用蜂胶的降解性。本课题首先对蜂胶的成分进行研究，以了解蜂胶的抗微生物特性。在第二阶段，将开发提取活性成分的方法，特别注意保留其生物活性。在最后阶段，将研究制造不同类型颗粒的复杂配方设计和配方路线，以便生产在食品、化妆品和制药应用中具有最佳活性的蜂胶和协同活性制剂的配方。

Bees are sociable insects that leave and work in the hive. In order to be protected from outside enemies such as bacteria, fungi and other microorganisms they seal the hive with propolis that the bees have to produce themselves. Propolis has all the antimicrobial and antibacterial properties required in addition to its resinous character to be used as a sealing material. In addition, propolis serves as an antioxidant agent due to its reducing character properties that are utilised by the bee hive. At first this project will investigate the composition of propolis in order to understand its anti-microorganism character. At a second stage methods will be developed in order to extract the active ingredients paying particular attention in the retention of their biological activity. At a final stage, complex formulation designs and formulation routes for the fabrication of different types of particles will be investigated, in order to produce formulations which are tailored to deliver propolis and synergistic active agents with optimised activity in the food, cosmetics and pharmaceutical applications.