UCSFCC/SFSU Collaborative Cancer Research and Training

本合作项目由加州大学旧金山弗朗西斯科癌症中心（UCSFCC）和旧金山弗朗西斯科州立大学（SFSU）共同开展。它将启动两个试点研究项目和两个规划和发展活动，为未来的合作博士前研究培训。试点研究项目将涉及SFSU/UCSFCC调查员的两个团队;这两个合作是新聘请的生物学SFSU助理教授和高级UCSF教员谁也是UCSFCC的成员，UCSF教授伊丽莎白·布莱克本，博士。将担任指导和共同研究员与莎莉激情，博士。来表征裂殖酵母DNA复制和修复突变体中的端粒末端。Wilfred Denetclaw博士（任命为SFSU生物学助理教授，2000年9月生效）将由前UCSF博士后导师Charles Ordahl教授指导。他们的合作研究项目将集中在生物标志物的dermomyotomal肌节祖细胞和他们的上皮细胞到间充质转化为肌节层。每个合作试点项目中的研究问题和指导承诺旨在测试在此P-20规划补助金的第三年期间提交的RO 1提案。学生研究培训将是本提案的规划和发展部分的重点。一个试点规划和发展活动将使用SFSU和UCSFCC教师的队列，为SFSU本科（MARC和MBRS-RISE）和SFSU MA/MS学位（NIH Bridge和MBRS-RISE）的学生开发一个更积极和协调一致的安置过程/计划，特别是进入UCSFCC实验室。为了在2001年6月开始这项活动，合作教师规划委员会审查和评估过去的参与，1）SFSU本科生（MARC和MBRS-RISE）在UCSF的夏季研究经验，2）其学术论文研究在UCSF教师实验室执行，并制定一项行动计划，将在渗透着癌症焦点的环境中发展强大的研究培训经验。第二个试点规划和发展活动将针对在该P-20项目的第三年期间提交联合R-25 E或R-25 T或T-32博士前培训提案。这一目标的实现将需要通过联合UCSFCC-SFSU教师会议和务虚会认真规划，以1）确定和优先考虑短期和长期的博士前学生癌症研究培训目标，2）制定相互接受的合作博士前癌症研究培训计划与R-25 E或R-25 T或T-32资助机制的指导方针。任何最终提案的核心要素将是招聘和保留战略的应用，这将导致博士学位中代表性不足的少数民族的入学人数增加。程序.

DESCRIPTION This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Developmental activities for future collaborative pre-doctoral research training. The pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations is between a newly hired SFSU Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC, UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentored and co-investigator with Sally Passion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutants. Wilfred Denetclaw, Ph.D. (Appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by this former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments build into each collaborative pilot project are designed to test in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Developmental components of this proposal. One pilot Planning and Development activity will use a cohort of SFSU and UCSFCC faculty to develop a more aggressive and concerted placement process/program for SFSU undergraduate (MARC and MBRS-RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically. In order to commence this activity in June 2001, the collaborative faculty planning committee review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS-RISE) in summer research experiences in UCSF and 2) whose academic thesis research was executed in UCSF faculty laboratories and develop an action plan that will develop a strong research training experience in an environment permeated with a cancer focus. The second pilot Planning and Development activity will be directed at the submission of a joint R-25E or R-25T or T-32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre- doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre-doctoral cancer research training program with the guidelines of the R-25E or R-25T or T-32 funding mechanisms. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented minorities in Ph.D. programs.