SPIRAL CT FOR COCHLEAR IMPLANTATION

描述：（根据申请人摘要） 多电极颅内植入物是有效治疗 耳聋，但结果因人而异。前后 手术螺旋CT可以提供耳蜗形态的3D图， 电极阵列在耳蜗中的位置，取决于分辨率 局限性。了解与耳蜗相关的3D电极位置 解剖学为建模和研究提供了基础， 电刺激参数来优化语音识别。 有一个关键和迫切的需要几何模型， 个体耳蜗在体内精确解剖定位 植入电极。这个几何模型是一个先决条件， 植入耳蜗的电解剖模型的开发， 有助于解释部分主体间语音识别差异。 电极阵列与颅内电极之间的几何关系 特征为合理设计干预措施提供了基础， 设备及其编程。 长期目标是确定植入耳蜗的形态， 使用该3D几何信息改进语音识别。的 具体目标是（1）在3D中定位植入电极， 手术X射线立体摄影测量，并将此信息 在相应的螺旋CT图像;（2）去模糊和展开耳蜗， 术前和术后的容积螺旋CT图像;（3）开发和 验证单个植入耳蜗的几何模型，以及 证明其在患者研究中的临床可行性和实用性。 将使用图像分辨率体模、 植入有各种类型的耳蜗植入物的人类耳蜗， 以及埋有这些模型和标本的尸体头部。 验证的金标准将由独立的 使用反射显微镜和微型CT获得的测量结果 幻影和标本。 完成后，植入的耳蜗形态将在 通过基于X射线合成个性化3D几何模型 立体摄影测量和螺旋CT。X射线成像和图像分析 植入前和植入后诊断和研究方法 应用程序将得到验证，并应用于患者研究。一张网- 人工耳蜗螺旋CT基础资源将推广 图像和建模技术和软件。

DESCRIPTION: (as per applicant abstract) Multi-electrode, intracochlear implants are effective treatment of deafness, but the results vary between individuals. Pre- and post- operative spiral CT can provide 3D maps of cochlear morphology and electrode array position in the cochlea, subject to resolution limitations. Knowledge of 3D electrode locations relative to cochlear anatomy provides the foundation for modeling and investigation of electrical stimulation parameters to optimize speech recognition. There is a critical and immediate need to geometrically model the individual cochlea in vivo with precise anatomic localization of implanted electrodes. This geometric model is a prerequisite for development of electroanatomic models of the implanted cochlea, and may help explain part of intersubject speech recognition variability. Geometric relations between an electrode array and intracochlear features provide the basis for rational design of interventions, devices, and their programming. The long term objective is to define implanted cochlear morphology and improve speech recognition using this 3D geometric information. The specific aims are to (1) localize implant electrodes in 3D with post- operative X-ray sterophotogrammetry, and incorporate this information in corresponding spiral CT images; (2) deblur and unwrap the cochlea in volumetric spiral CT images pre- and post-operatively; (3) develop and validate geometric models of individual implanted cochleas, and demonstrate their clinical feasibility and utility in patient studies. Validation will be done with immage resolution phantoms, specimens of the human cochleas implanted with various types of cochlear implants, and cadaver heads in which these phantoms and specimens are embedded. The gold standard for validation will be established by independent measurements obtained using Reflex microscopy and micro CT of these phantoms and specimens. On completion, implanted cochlear morphology will be characterized in vivo by synthesizing individualized 3D geometric models based on X-ray stereophotogrammetry and spiral CT. X-ray imaging and image analysis methods for pre- and post-implantation diagnostic and research applications will be validated, and applied in patient studies. A Web- based resource of spiral CT for cochlear implantation will disseminate the image and modeling techniques and software.