HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATION

这是培养心血管和呼吸系统综合生理学研究生和博士后的新应用。该计划的目标是为一组选定的前和博士后学员提供在分子，细胞，器官和整个动物和人类水平上心肺系统功能整合的强化和优秀培训。该计划的主要优势是培训教师的可用性和他们研究动物心肺系统生理学的能力，并有针对性地操纵基因，从而将遗传和分子生物学信息整合到生理功能中。来自凯斯西储大学医学院6个基础系和2个临床系的19名教师参与了该项目。这些学科包括生理学和生物物理学、神经科学、营养学、生物医学工程、解剖学、生物化学、医学和儿科学。许多参与的教师有长期富有成效的合作互动，并以跨学科的方式培养了许多成功的研究人员和医生科学家。他们都有活跃和完善的实验室，提供最先进的心肺生理学研究培训，使用人体和/或动物模型。该培训计划将成为汇集这些研究人员的机制，并将对心肺生理学的培训和未来研究产生重大影响。本申请寻求8名博士生和/或博士后。博士预科生将被招收为新开发的系统集成生理学研究生课程的博士研究生。博士前培训包括专门为心肺生理学综合方面设计的高级课程，分子和细胞生物学基础，实验室轮转，研讨会和指导研究。本项目博士后培养对象分为三种：1)攻读博士学位的博士研究生；2)从事2年全职博士后研究的心脏科和/或肺科临床研究员；3)博士、博士后。专门的高级课程，活跃的研讨会和期刊俱乐部将补充博士后培训。我们认为，我们提出的培训计划，强调跨越部门障碍和科学学科，是成功培训研究人员在心肺系统生理学综合方面的必要条件。

This is a new application for training graduate and post-doctoral fellows in integrated physiology of cardiovascular and respiratory systems. The goal of this program is to provide a selected group of pre and postdoctoral trainees with intensive and excellent training in integration of function of the cardio-respiratory systems at the molecular, cellular, organ and whole animal and human levels. The major strength of the proposed program is the availability of training faculty and their ability to study physiology of the cardio-respiratory systems in animals with targeted manipulation of genes allowing integration of genetic and molecular biological information into physiological functions. There are 19 participating faculty in this program from 6 basic and 2 clinical science departments at the School of Medicine at Case Western Reserve University (CWRU). These include Physiology & Biophysics, Neurosciences, Nutrition, Biomedical Engineering, Anatomy, Biochemistry, Medicine, and Pediatrics. Many of the participating faculty has long term productive collaborative interactions and trained a number of successful research and physician-scientists in an interdisciplinary manner. They all have active and well-founded laboratories providing state-of-the-art research training in cardiopulmonary physiology using human and/or animal models. This training program will be a mechanism to bring together these investigators and will have a major impact on training and future research in cardio-pulmonary physiology. This application seeks eight pre- and/or postdoctoral trainees. The predoctoral students will be enrolled as Ph.D. students in a newly developed Systems Integrated Physiology graduate program. Predoctoral training includes advanced courses specifically designed for integrated aspects of cardio- respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, and guided research. Postdoctoral trainees in this program are of three kinds: 1) MD's entering a specialized Ph.D. program; 2) cardiology and/or pulmonary clinical fellows receiving 2 years full time research as postdoctoral trainees; 3) Ph.D. postdoctoral trainees. Special advanced courses, active seminar sessions and journal clubs will supplement postdoctoral training. We believe, our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines is necessary for the successful training of researchers in integrated aspects of the physiology of the cardio-respiratory systems.