Postdoctoral Hematology Research Training

（申请人？s摘要） 本博士后培训项目的培训人员已培训了119名学员 在过去的十年里。其中55人活跃于学术研究，44人是 工业实验室主任和20名从事服务和研究的实验室主任。我们 建议继续进行止血方面的博士后培训计划， 俄克拉荷马州健康科学大学校园内的血栓形成 中心，（OUHSC）医学博士和博士寻求血液学职业的候选人 研究和谁愿意研究淋巴细胞，功能和机制， 止血，包括血浆蛋白与血管 内皮/血小板。该计划分为三个轨道。1. 止血蛋白（结构和功能），包括血栓调节蛋白， 内皮蛋白C受体，蛋白C和S，因子V和VIII/vWF， 组织因子/因子VII和血小板P-选择素。2.受体/配体的作用 血小板、内皮细胞和淋巴细胞功能。中的早期事件 骨髓基质细胞和淋巴细胞的分化。3.动物/临床 研究，包括蛋白C和S缺乏症，以及患者中的因子VIla 与血栓形成和血管变性疾病，蛋白C的作用， 血栓形成和肿瘤疾病的网络，以及狒狒的反应 注入了大肠杆菌该计划将为培训生的职业生涯做好准备， 学术医学和止血研究。受训人员从下列人员中选出： 医生谁有至少两年的博士后培训， 直接的内科、外科或儿科住院医师项目和博士学位？年代 生物化学、病理学、生理学或微生物学。根据本 根据平权行动的原则，我们积极寻求女性和少数民族 申请者我们用于成功完成培训的标准 有能力管理自己的实验室，撰写自己的资助申请 并在基础科学和研究方面开展自己的独立研究 面向临床科室。 根据工作表现，允许进行两到三年的培训。M.D. 受训人员在此期间没有任何正式的病人护理责任。 培训计划。该培训计划由心血管 俄克拉荷马州医学研究基金会（OMRF）的生物学研究组， OUHSC校园这个小组位于一楼和二楼的 Acree/Woodworth大楼，OMRF。这是行政和 会议中心的培训补助金。实验室研究培训 也是在医学系和圣路易斯大学的实验室进行。 弗朗西斯堡（OUHSC）。全体教职员工紧密合作， 专业研究中心（SCOR）和计划项目（PP）。

(Applicant?s Abstract) The trainers of this Post Doctoral Training program have trained 119 trainees over the last ten years. 55 of whom are active in academic research, 44 are laboratory directors in industry and 20 perform service and research. We propose to continue a postdoctoral training program in hemostasis and thrombosis on the Campus of the University of Oklahoma Health Sciences Center,(OUHSC) for M.D. and Ph.D. candidates who seek careers in hematological research and who wish to study on lymphocyte, function and mechanisms of hemostasis including the interaction of plasma proteins with vascular endothelium/platelets. This program is divided into three tracks. 1. Hemostatic proteins (structure and function) including thrombomodulin, endothelial protein C receptor, proteins C and S, factors V and VIII/vWF, tissue factor/factor VII and platelet p-selectin. 2. Role of receptor/ligands in platelet, endothelial cell and lymphocyte function. Early events in differentiation of marrow stromal cells and lymphocytes. 3. Animal/clinical studies, including protein C and S deficiencies, and factor VIla in patients with thrombotic and vascular degenerative disorders, the role of the protein C network in thrombotic and neoplastic diseases, and in the response of baboons infused with E.coli. This program will prepare the trainee for a career in academic medicine and hemostasis research. Trainees are selected from physicians who have had at least two years of postdoctoral training in straight medical, surgical or pediatric residency programs and from PhD?s in biochemistry, pathology, physiology, or microbiology. In accordance with the principle of affirmative action, we actively seek female and minority applicants. The criteria which we use for successful completion of training are the ability to run their own laboratory, write their own grant proposals and carry out their own independent research in basic science and research orientated clinical departments. Two to three years of training are allowed on the basis of performance. M.D. trainees do not have any formal patient care responsibilities while on this training program. This training program is implemented by the Cardiovascular Biology Research group of the Oklahoma Medical Research Foundation, (OMRF) on the OUHSC campus. This group is located on the lst and 2nd floors of the Acree/Woodworth Building, OMRF. This serves as the administrative and conference center for the training grant. Training in laboratory research also is conducted in the laboratories of the Department of Medicine and St. Francis Fdt. (OUHSC). All members of the faculty work closely together under Specialized Center of Research (SCOR) and Program Project (PP).