PATHOGENESIS OF SV40 INFECTIONS IN MACAQUES W/ AIDS

灵长类多瘤病毒包括JCV和BKV，它们可以感染 人，与猕猴的SV40密切相关的免疫活性 宿主，原发感染发生在生命早期，轻度或无感染 临床症状，然后病毒持续作为一种潜伏感染，主要是 肾脏重新激活和病毒脱落可能会在怀孕时发生， 慢性病或免疫功能受损，可能与此相关，也可能不相关 有临床症状的JCV与进行性多灶性疾病有关 白质脑病(PML)是一种中枢神经系统脱髓鞘疾病 少突胶质细胞感染导致的神经系统(CNS)，高达5% 在艾滋病患者中，BKV导致间质性肾炎和/或出血性 膀胱炎，特别是在移植受者中，同样，SV40是 与PML和肾炎相关的SIV感染猕猴 猴艾滋病以前的研究表明，SV40导致间质 原发感染中的肾炎和潜伏期重新激活的PML 感染SIV的猕猴的感染现在我们认识到第二个中枢神经系统 影响大脑灰质的SV40A型脑膜脑炎的临床表现 没有脱髓鞘的物质，与PML不同，这种损害可以是一种 SV40合并SV40诱导的主要表现 间质性肾炎SV40的原位杂交 胶质纤维酸性蛋白的免疫组织化学研究 部分显示，许多受感染的细胞在 脑膜脑炎病变是星形胶质细胞，与PML相反，PML 大多数感染细胞是少突胶质细胞。

The primate polyomaviruses include JCV and BKV, which infect humans, and the closely related SV40 of macaques In immunocompetent hosts, primary infection occurs early in life, with mild or absent clinical signs The virus then persists as a latent infection mainly in kidney Reactivation with viral shedding can occur with pregnancy, chronic diseases or immunocompromise, and may or may not be associated with clinical signs JCV is associated with progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system (CNS) due to infection of oligodendrocytes, in up to 5% of AIDS patients BKV causes interstitial nephritis and/or hemorrhagic cystitis, particularly in transplant recipients Similarly, SV40 is associated with both PML and nephritis in SIV-infected macaques with simian AIDS Previous studies indicated that SV40 causes interstitial nephritis in primary infections, and PML upon reactivation of a latent infection in SIV-infected macaques We now recognize a second CNS manifestation of SV40 a meningoencephalitis affecting cerebral gray matter, without demyelination, distinct from PML This lesion can be a primary manifestation of SV40 in conjunction with SV40-induced interstitial nephritis In situ hybridization for SV40, coupled with immunohistochemistry for glial fibrillary acidic protein on the same section, demonstrates that many of the infected cells in the meningoencephalitic lesions are astrocytes, in contrast to PML, where the majority of infected cells are oligodendrocytes