Promoting and Controlling Vascularisation in Engineered Tissues

研究领域：生物材料和组织工程工程组织的血管化方法长期以来一直被寻求，以实现与宿主血管的融合并防止植入后缺氧。尽管取得了一些成功，但为了优化细胞类型、流体流动和血管生成因子的数量的组合和比例，以获得完全可灌注和稳定的血管网络，方法仍然在很大程度上受试验和错误的驱动。这个项目的目的是使用计算模型，结合实验，模拟血管生成，反过来，回答一些复杂的问题，关于优化相关的物理参数，以确保植入组织的短期和长期生存。为了实现这一目标，该项目试图通过结合文献中建议的其他补充机制来解决现有模型之间的差异。此外，我们试图使用计算模型来研究哪些因素在植入体内后对网络的生存和稳定性起关键作用。

Research Area: Biomaterials and tissue engineeringMethods of vascularisation of engineered tissue have long been sought after to enable inosculation with host vessels and prevent hypoxia after implantation. Despite some successes, methods remain very much driven by trial and error in order to optimise the combination and ratio of cell types, fluid flow and the quantities of angiogenic factors, to obtain a fully perfusable and stable vascular network. The aim of this project is to use computational modelling, in conjunction with experiments, to model vasculogenesis and, in turn, answer some of the complex questions regarding optimising the relevant physical parameters to ensure both short- and long-term survival of the implanted tissue. To achieve this, the project seeks to address discrepancies between existing models by incorporating other complementary mechanisms suggested in the literature. Furthermore, we seek to use computational modelling to investigate which factors play a key role in the survival and stability of the network once implanted in vivo.