Platform technologies for multifunctional nanocarrier systems

智能靶向纳米载体为药物递送提供了新的机会。该项目旨在开发可重复生产和筛选靶向纳米载体的新平台。该项目开发的平台技术旨在彻底改变目前设计和评估药物递送系统的策略，并将加速靶向药物递送的临床转化。这将包括一种新的一步微流控平台技术，用于可重复地生产具有系统性变化特性的靶向聚合物纳米载体，用于制造靶向二氧化硅纳米载体的双模板方法，以及用于筛选和评估纳米载体的体内模拟“组织芯片”的新设计。

Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.