DIET AND DURATION OF CERVICAL HPV INFECTION

描述：（改编自研究者摘要）本项目将 建立一个多族裔妇女队列，进行长期跟踪， 影响人乳头瘤病毒持续存在或消退的因素 (HPV)子宫颈感染。 具体目标是：（1）研究 水果和蔬菜的饮食摄入量， HPV感染者血浆类胡萝卜素、α-生育酚和维生素C水平 持久性; 2）检查HPV类型，数量（病毒载量）的作用， HPV持续性中的多种（同步）HPV感染;以及3）检查 营养（例如，β-胡萝卜素）和病毒（例如，HPV 16)HPV持续感染的风险因素。 一个由1,152名年龄在18岁及以上的HPV阳性妇女组成的多种族队列， 在妇产科诊所的患者中建立 檀香山三家大型医疗中心 该队列将包括 相当数量的亚洲人（日本人、菲律宾人、中国人、韩国人） 波利尼西亚（夏威夷，萨摩亚）和高加索妇女。 则将队列 纵向随访，基线时收集以下数据，月 4个月、8个月、12个月、24个月和36个月（6次访视）：（a）宫颈 细胞学（Pap）涂片，用于病理学检查;（B）阴道镜检查 （c）子宫颈的可视化，以确认细胞学; 用于HPV DNA分析的样品;和（d）用于测量微量营养素的血液样品 程度. 将在基线时进行简化问卷调查， 将在第4个月进行一次扩大访谈，包括以下信息 饮食、吸烟和饮酒以及性和生殖史。 节食 在每次年度访问中，将进行历史和后续访问。 从队列成员中获得的宫颈活检标本将由 研究病理学家和切片将免费存档， 本研究。 对数据的分析将侧重于对饮食和血浆的评价。 微量营养素水平和病毒特性，影响 使用广义估计方程（GEE）评估HPV感染的持续性 一种校正重复测量之间相关性的方法。 这些因素的识别可能会提供洞察自然 HPV感染史，并可能提高我们对女性特征的能力 最有可能发展成HPV相关肿瘤的人群。 等 知识也可以帮助发展适当的筛选 涉及HPV DNA检测的策略，可以针对 将最受益于密集的后续行动。

DESCRIPTION: (Adapted from Investigator's Abstract) This project will establish a multiethnic cohort of women for long-term follow-up to identify factors that influence the persistence or resolution of human papillomavirus (HPV) infection of the uterine cervix. The specific aims are to 1) study the association of the dietary intake of fruits and vegetables, and the plasma levels of carotenoids, alpha-tocopherol, and vitamin C with HPV persistence; 2) examine the role of HPV type, quantity (viral load), and multiple (synchronous) HPV infections in HPV persistence; and 3) examine the interaction between nutritional (e.g., beta-carotene) and viral (e.g., HPV 16) factors on the risk of persistent HPV infection. A multiethnic cohort of 1,152 HPV-positive women, aged 18 and older, will be established among patients attending the obstetrics and gynecology clinics of three large medical centers in Honolulu. The cohort will include appreciable numbers of Asian (Japanese, Filipino, Chinese, Korean) Polynesian (Hawaiian, Samoan) and Caucasian women. The cohort will be followed longitudinally with the following data collected at baseline, month 4, month 8, month 12, month 24 and month 36 (6 visits): (a) a cervical cytological (Pap) smear for pathological review; (b) colposcopic visualization of the cervix for confirmation of cytology; (c) a cervical sample for HPV DNA analysis; and (d) a blood sample to measure micronutrient levels. An abbreviated questionnaire will be administered at baseline and an expanded interview will be conducted at month 4 including information on diet, tobacco and alcohol use, and sexual and reproductive history. A diet history and follow-up interview will be conducted at each annual visit. Cervical biopsy specimens obtained from cohort members will be reviewed by the study pathologist and sections will be archived at no cost to the present study. Analysis of the data will focus on the evaluation of dietary and plasma micronutrient levels and viral characteristics that influence the persistence of HPV infection using a generalized estimating equation (GEE) approach that corrects for the correlation between the repeated measures. The identification of these factors may provide insight into the natural history of HPV infection, and may improve our ability to characterize women who are at greatest risk for developing HPV-associated neoplasia. Such knowledge may also assist in the development of appropriate screening strategies involving HPV DNA detection that could be targeted at women who would benefit most from intensive follow-up.