NEW TECHNIQUES IN DIAGNOSING OSTEOARTHRITIS: MONKEY MODEL

超极化（HP）惰性气体的磁共振成像 一个很好的肺部成像工具。 用于优化成像 策略，如投射编码或快速梯度回忆 回波序列，用于获取肺部形态图像 气体空间，了解体内肺中的弛豫时间， 不同的生理条件是至关重要的。 3 He的依赖性， 129 Ω纵向弛豫速率随分子浓度的变化 稀有气体/O2混合物中的氧是众所周知的。 假设偶极子 与顺磁O2耦合是HP的主要贡献 惰性气体T1在肺部气体空间，确定T1将进一步 提供了一种非侵入性技术，用于测量 氧（PO 2）在体内肺。 因此，该项目的目的是 在豚鼠体内肺中测定不同浓度的~ 3 He和~（129）Tc ~ 1， 暂停呼吸期间的氧气水平。 第一 实验将采用非定域光谱法进行 技术. 基于这些结果，单次激发成像技术， 例如螺旋投影编码，将被开发用于进一步 分别向区域T1和PO 2的地图延伸。

Magnetic resonance imaging of hyperpolarized (HP) noble gases is an excellent tool for pulmonary imaging. For optimization of imaging strategies, such as projection encoding or rapid gradient-recalled echo sequences, used to acquire morphologic images of the pulmonary gas space, knowledge of the relaxation times in the lung in vivo under varying physiologic conditions is crucial. The dependence of 3He and 129Xe longitudinal relaxation rates upon the concentration molecular oxygen in noble gas/O2 mixtures is well known. Assuming that dipolar coupling with paramagnetic O2 is the dominating contribution to HP noble gas T1 in lung gas spaces, determination of T1 would further provide a non-invasive technique for measuring the partial pressure of oxygen (PO2) in the lung in vivo. Purpose of the project is therefore to measure 3He and 129Xe T1 in the guinea pig lung in vivo at varying oxygen levels during periods of suspended breathing. First experiments will be performed with non-localized spectroscopy techniques. Based upon these results, single-shot imaging techniques, such as spiral projection encoding, will be developed for further extension toward maps of the regional T1 respectively PO2.