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CRYSTAL STRUCTURE OF CYTOSKELETAL PROTEIN, VINCULIN

CRYSTAL STRUCTURE OF CYTOSKELETAL PROTEIN, VINCULIN
细胞骨架蛋白，纽蛋白的晶体结构
批准号：
6483549
负责人：
ROBERT Colin LIDDINGTON
金额：
$12.06万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-08-15 至 2002-08-14
来源：
https://reporter.nih.gov/project-details/6483549
关键词：
biomedical resource structural biology

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中文摘要
翻译
纽蛋白是一种相对分子质量为120 KDa的大蛋白，结构未知， 它在局灶性粘连的组装过程中起着核心作用。这些 是在细胞-基质连接处发现的大分子络合物，它 在细胞外之间提供结构和功能上的联系 矩阵和肌动蛋白细胞骨架。关于绑定，我们知道的很多 纽蛋白的体外活性，该领域已经做好了准备 受益于原子分辨率的结构数据，这将 阐明焦点黏附组装的结构基础和 调节
英文摘要
Vinculin is large protein of MW 120 KDa, of unknown structure, which plays a central role in the assembly of focal adhesions. These are macromoleular complexes found at cell-matrix junctions, which provide a structural and functional link between the extracellular matrix and the actin cytoskeleton. Much is known about the binding activities of vinculin in vitro, and the field is well poised to benefit from structural data at atomic resolution, which would elucidate the structural basis of focal adhesion assembly and regulation
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