ROLE OF HUMAN MILK IN INFANT NUTRITION AND HEALTH

我们的计划项目补助金申请的竞争性更新是 由提议继续进行研究的研究人员提交 人乳的独特性质。所有项目都涉及生物 通过使用体外试验、动物试验和动物试验的方案 模型和人类。这些项目通常寻求定义和描述 母乳中的一些因子可以保护新生儿免受疾病的侵害。某些 管腔乳胃肠道相互作用的后果， 保护儿童的工作将继续进行。动物 模型将用于人类受试者的研究是不可能的，但 将在适当的时候研究人类婴儿。相应 项目和分包商将考虑：1）可溶性牛奶的作用 预防志贺氏菌病的因素; 2）抗炎 母乳的特性; 3）分泌免疫系统的作用 在病毒性肠道病原体感染中; 4）分离、表征和 人乳中抗热稳定性 肠毒素E. 5）母乳在预防大肠杆菌感染中的作用 弯曲杆菌感染。每个项目都将得到以下方面的支持： 流行病学/统计学、生物化学和分子生物学核心 路段

The competitive renewal of our program project grant application is submitted by investigators who propose to continue their studies on the unique properties of human milk. All projects address the biologic consequences through protocols which utilize in vitro assays, animal models, and humans. The projects generally seek to define and characterize factors in human milk that protect newborn infants from disease. Certain consequences of the luminal milk gastrointestinal tract interactions that pertain to protection of the infant will continue to be examined. Animal models will be utilized with study of human subjects is not possible, but human infants will be studied whenever appropriate. The respective projects and subcontracts will consider: 1) the role of soluble milk factors in the prevention of shigellosis; 2) the anti-inflammatory characteristics of human milk; 3) the role of the secretory immune system in viral enteric pathogen infection; 4) isolation, characterization and testing of the protective factor(s) in human milk against heat-stable enterotoxin of E. coli; and 5) the role of human milk in the prevention of Campylobacter infection. Each of the projects will be supported by epidemiology/statistical, biochemical, and molecular biology core sections.