COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL

描述（改编自申请人的摘要）：一个关键的密集计划， 目前TRS乳腺癌成像仪的改进将增加 检测器、动态范围和测量的参数数量， 更高的精度、分辨率、覆盖范围、动态范围和功能 检测能力的基础上吸收和荧光研究 内在和外在造影剂。将对这些改进进行评估 一个接一个地通过计算机模拟和轶事人类主题研究。 增加成像性能将使用微扰扩散 光学层析成像（DOT），并将测试与单一和多个光学 作为源探测器对，投影角， 频率和信噪比。这些改进也将得到检验 利用这些工具， 和理论上的改进，其中与钆的配准增强 MRI、氟脱氧葡萄糖、PET和组织病理学提供了金标准。轶事 然后将对临床数据进行处理，用于a）图像重建，以及B） 在MRI指定的体素拟合程序。主映像和拟合将 基于钆增强MRI的评价，或 组织病理学。其他特征，特别是肿瘤氧合， 将比较血红蛋白饱和度估计值，用于成像 重建，采用PET，对于肿瘤诊断能力， 组织病理学一个类似的两层分析将作出光散射 在正常和乳腺激活的乳房中。这样，DOT的能力 对于图像重建和特征提取， 确保这些治疗乳腺癌的新方法得到验证的研究 侦测大规模测试可在其他支持下进行， 不仅与MRI进行比较，还与数字乳腺X线摄影、超声和PET进行比较 确保验证研究的安全

DESCRIPTION (Adapted from Applicant's Abstract): An intensive program of key improvement of the current TRS breast cancer imager will increase the number of detectors, the dynamic range, and the number of parameters measured leading to increased accuracy, resolution, area of coverage, dynamic range and feature detection ability based upon both absorption and fluorescence studies of intrinsic and extrinsic contrast agents. These improvements will be evaluated one by one by computer simulation and anecdotal human subject studies. Increased imaging performance will be studied using perturbative diffusive optical tomography (DOT) and will be tested with single and multiple optical heterogeneities as a function of source detector pairs, projection angles, frequencies and signal to noise ratios. These improvements will also be tested with anecdotal DOT images of human breast tumor exploiting these instrumental and theoretical improvements in which coregistration with gadolinium enhanced MRI fluorodeoxy glucose PET and histopathology afford gold standards. Anecdotal clinical data will then be processed for a) image reconstruction, and b) fitting procedures in MRI designated voxels. The primary images and fits will be based upon evaluation with gadolinium enhanced MRI or and with histopathology respectively. Other features, especially tumor oxygenation as estimated from hemoglobin saturation will be compared, for imaging reconstruction, with PET and, for tumor diagnostic capability, with histopathology. A similar two tiered analysis will be made of light scattering in normal and hormonally activated breast. In this way the capability of DOT for image reconstruction and feature extraction will be evaluated with adequate studies to ensure validation of these novel approaches to breast cancer detection. Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies.