Endocrinological aspects of behavioral dysregulation during early development

产品描述：该建议旨在研究100名6个月至2岁婴儿的队列中生物，心理和社会功能的相互关系，以及第二个6，15和24个月大的150名受试者的横断面队列。研究这些队列的目的是描述与婴儿特征相关的神经内分泌指标，这些指标可能使他们容易出现心理健康问题。受试者和他们的照顾者使他们容易出现心理健康问题。将使用唾液皮质醇和实验室应激程序（母体分离和母体静止面部）对受试者及其看护者进行评估，试图描述和解释看护者特征与定义失调结构的婴儿调节特征（睡眠、喂养、喂养和哭泣）的相互作用。此外，该研究旨在探讨儿童昼夜节律的建立和可预测性，作为稳定的基础皮质醇水平的前提，表明“反应性较低”的压力LHPA轴。

Description: This proposal seeks to examine the interrelations of biological, psychological, and social functioning in a cohort of 100 infants from 6 months to 2 years, and a second cross-sectional cohort of 150 subjects at 6, 15, and 24 months of age. The purpose of studying these cohorts is to delineate neuroendocrine measures that are linked to characteristics of infants that may predispose them to mental health problems. The subjects and their caretakers predispose them to mental health problems. The subjects and their caretakers will be assessed using salivary cortisol and a laboratory stress procedure (maternal separation and maternal still face) in an attempt to describe and explain the interaction of caregiver characteristics with infant regulatory features (sleeping, feeding, feeding, and crying) that define a construct of dysregulation. In addition, the study seeks to explore the establishment and predictability of circadian rhythms in children as an antecedent to stable basal cortisol levels indicative of a "less reactive" stress LHPA axis.