PLATELET, SHEAR STRESS, AND ARTERIAL THROMBOSIS

这项提议是在德克萨斯医学中心建立一个专门的止血和血栓疾病研究中心，总部设在休斯敦的贝勒医学院。该提案侧重于动脉血栓形成的过程，从由血小板膜糖蛋白(GP)Ib-IX-V复合体和内皮下von Willebrand因子(VWF)介导的血小板黏附的初始步骤开始，最终形成纤维蛋白交联的血栓，可能完全闭塞血管并导致组织梗塞。除了研究血栓形成的基本机制外，我们还将研究两种临床疾病，一种是血栓形成的后果，即血栓性微血管病变，另一种是合并血栓形成，即外周动脉疾病。

This proposal is to establish a Specialized Center of Research in Hemostatic and Thrombotic Diseases in the Texas Medical Center, based at the Baylor College of Medicine, Houston. The proposal focuses on the process of arterial thrombosis, beginning with the initial step of platelet adhesion mediated by the platelet glycoprotein (GP) Ib-IX-V complex and subendothelial von Willebrand factor (vWF), and culminating in the formation of a fibrin cross-linked thrombus that may completely occlude a blood vessel and cause tissue infarction. In addition to examining basic mechanisms of thrombus formation, we will investigate two clinical disorders, one a consequence of thrombosis, the thrombotic microangiopathies, and one complicated by thrombosis, peripheral arterial disease.