CLINICIAN MANAGED INTERPERSONAL PSYCHOTHERAPY

描述（改编自申请人摘要）：实证研究 评估急性心理治疗的效果提供了 这些宝贵的数据证明了这种治疗对主要疾病的疗效， 萧条在受控条件下，限时手动 心理治疗在缓解抑郁症方面是有效的。 症状然而，这种功效研究有几个局限性。第一、 尽管这些治疗在实验室环境中是有效的， 在这些治疗中，疗效研究受到缺乏外部证据的限制。 效度第二，虽然有时间限制的治疗对 抑郁症是令人印象深刻的，改善往往不能维持， 症状复发是常见的。 我们提出的研究项目是一个实证调查的 临床医生管理的人际心理治疗（CM-IPT）对 产后抑郁症，一种基于Klerman等人手册的治疗方法（1）， 为社区环境而精心打造。会议的时间和频率将 由治疗师和患者共同决定，而不是任意决定 由手动指令指定。我们将评估12项措施的有效性。 与“标准”相比， IPT治疗产后抑郁症，我们以前有一种治疗方法， 与等待列表控制条件相比，证明是有效的。 标准IPT将要求在前12个月内提供2个IPT课程 治疗分配后2周。 本研究应用的第一个主要目的是评估 CM-IPT治疗产后抑郁症的纵向有效性与 标准IPT。我们预测CM-IPT将与较低的累积 第一年的抑郁症状水平和抑郁率较低 比标准的IPT。本研究申请的第二个主要目的是 证明CM-IPT对产后抑郁症的急性有效性。我们 将在治疗分配后12周比较CM-IPT和标准IPT (the标准IPT治疗的结论），届时我们预计 治疗应具有临床等效性。我们的研究，独特地结合了 有效性和有效性研究的最佳元素，将导致更多 在社区中为产后抑郁的妇女提供有效的治疗。

DESCRIPTION (Adapted from the Applicant's Abstract): Empirical studies evaluating the effects of acute psychotherapeutic treatment have provided invaluable data demonstrating the efficacy of such treatments for major depression. Under controlled conditions, time-limited manual-based psychotherapies are efficacious in bringing about remission of depressive symptoms. Such efficacy studies, however, have several limitations. First, though the treatments are efficacious in laboratory settings, the effectiveness of such treatments, efficacy studies are limited by their lack of external validity. Second, though the acute effects of time-limited treatments for depression are impressive, the improvement is often not maintained, and recurrence of symptoms is common. Our proposed research project is an empirical investigation of the effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) for postpartum depression, a treatment based on the manual of Klerman et al (1) and refined for a community setting. Timing and frequency of sessions will be determined collaboratively by the therapist and patient rather than arbitrarily specified by manualized directives. We will evaluate the effectiveness of 12 sessions of CM-IPT delivered over the course of a year compared to "standard" IPT for postpartum depression, a treatment which we have previously demonstrated to be efficacious compared to a waiting list control condition. Standard IPT will require that 2 sessions of IPT be delivered in the first 12 weeks after treatment assignment. The first major aim of this research application is to evaluate the longitudinal effectiveness of CM-IPT for postpartum depression compared to standard IPT. We predict that CM-IPT will be associated with lower cumulative levels of depressive symptoms and lower rates of depression over the first year than standard IPT. The second major aim of this research application is to demonstrate the acute effectiveness of CM-IPT for postpartum depression. We will compare CM-IPT and standard IPT at 12 weeks after treatment assignment (the conclusion of standard IPT treatment), at which time we expect the two treatments to be clinically equivalent. Our study, which uniquely combines the best elements of both efficacy and effectiveness research, will lead to more effective treatment for depressed postpartum women in the community.