PACIFIC OVARIAN CANCER RESEARCH CONSORTIUM

太平洋卵巢癌研究联盟(POCRC)是由弗雷德·哈钦森癌症研究中心(FHCRC)领导的五个非营利性组织组成的联盟，包括华盛顿大学(UW)、瑞典医学中心(SMC)、太平洋西北研究所(PNRI)和雪松西奈医学中心(CSMC)。POCRC由来自不同学科的一群敬业和热情的科学家组成，他们聚集在一起，解决我们认为在控制卵巢癌方面最关键的问题。我们已经确定了五个我们有机会做出改变的领域。第一个是鉴定和阐明介导化疗耐药的基因的功能(项目1)。第二个是开发最终用于卵巢癌预防的核酸疫苗的方法(项目2)。第三是开发估计卵巢风险的工具，以支持筛查和预防试验，以证明降低卵巢癌发病率和死亡率的干预措施的有效性(项目3)。第四项是制定统计方法，选择要纳入筛查小组的卵巢癌标志物，并为妇女个人量身定做小组的使用，以提高筛查的效力和成本效益(项目4)。第五项是一项权威性研究，以证明旨在改善晚期卵巢癌患者生活质量的促进型团体咨询干预的有效性或缺乏(项目5)。该项目的总体挑战是保持科学家之间的高水平互动，并在整个团队中迅速交流新发现。领导力核心将作为科学互动、指导、指导和项目开发的基础。临床核心将提供协调和全面的程序，以便与医生合作，确定符合条件的妇女参加孢子中的各种研究研究和活动，并与医生互动，确定符合条件的妇女参加孢子中的各种研究研究和活动，并与华盛顿州的医生和卫生保健提供者互动，将研究结果传回社区。标本核心将收集、管理和分析组织和血液产品，以支持孢子研究项目。

The Pacific Ovarian Cancer Research Consortium (POCRC) is a consortium of five non-profit organizations led by the Fred Hutchinson Cancer Research Center (FHCRC), including the University of Washington (UW), Swedish Medical Center (SMC), Pacific Northwest Research Institute (PNRI), and Cedars Sinai Medical Center (CSMC). POCRC consists of a group of dedicated and enthusiastic scientists from a variety of disciplines who have come together to address the issues that we view as most critical in controlling ovarian cancer. We have identified five areas where opportunities exist for us to make a difference. The first is the identification and elucidation of the function of the genes that mediate chemo-resistance (Project 1). The second is the development of methods to create nucleic acid vaccines to be used eventually in ovarian cancer prevention (Project 2). The third is development of tools to estimate ovarian risk to support the screening and prevention trials that will be required to demonstrate the efficacy of interventions to reduce incidence and mortality from ovarian cancer (Project 3). The fourth is the development of statistical methods for selecting ovarian cancer markers to be included in a screening panel, and for tailoring the use of the panel to the individual woman to improve the efficacy and cost-effectiveness of screening (Project 4). The fifth is performance of a definitive study to demonstrate the efficacy or lack thereof of a facilitated group counseling intervention designed to improve advanced ovarian cancer patients' quality of life (Project 5). The overall challenge of the program is to maintain a high level of interaction among scientists and rapidly communicate novel discoveries throughout the group. A Leadership Core will act as the foundation for scientific interaction, direction, mentoring, and program development. A Clinical Core will provide coordinate and comprehensive procedures for working with physicians to identify eligible women for enrollment in various research studies and activities in the SPORE and interact with the physicians to identify eligible women for enrollment in various research studies and activities in the SPORE and interact with the physicians and health care providers in Washington State to translate the research findings back to the community. A Specimen Core will collect, manage, and analyze tissue and blood products in support of the SPORE research projects.