Leadership and Administration Core

领导和行政核心

基本信息

批准号：
7727536
负责人：
Nicole Denise Urban
金额：
$ 8.07万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7727536
关键词：
Achievement Address Advertising Advocacy Advocate Affect Arts Award Awareness Biological Blood Blood specimen Cancer Advocacy Cancer Center Support Grant Cancer Patient Caring Charge Clinic Clinical Collaborations Commit Committee Members Communication Communities Community Outreach Community Physician Databases Dedications Detection Development Directories Discipline District of Columbia Early Diagnosis Educational workshop Electronics Encapsulated Enrollment Ensure Epidemiology Equipment and supply inventories Event Family Family member Feedback Fees Friends Funding Genomics Goals Grant Health Fairs High Risk Woman Hospitals Hour Image Immunology Immunotherapy Individual Informatics Institution Instruction International Internet Intervention Investments Joints Laboratories Leadership Learning Letters Life Link Location Logistics Mails Malignant Neoplasms Malignant neoplasm of ovary Medical Dictionaries Medical center Mentors Mentorship Methods Modeling Molecular Profiling Monitor Names Nature Neoadjuvant Therapy Newsletter Operations Research Organ Outcome Ovarian Pamphlets Participant Pathology Patient Care Patient advocacy Patients Pattern Persons Phase Phase I Clinical Trials Physicians&apos Offices Pilot Projects Population Principal Investigator Process Productivity Prostate Proteomics Public Health Publications Published Comment Published Directory Quality of life Recruitment Activity Recurrence Reporting Reproduction spores Research Research Activity Research Ethics Committees Research Personnel Research Project Grants Research Proposals Resource Allocation Resource Sharing Resources Review Committee Risk Role Schedule Science Scientific Evaluation Scientist Screening procedure Series Serum Markers Site Specialist Specific qualifier value Specimen Specimen Handling Statistical Methods Structure Suggestion Surgeon Survivors Testing Time Translating Translational Research Universities Update Woman Work Writing abstracting anticancer research base cancer care career development cost efficacy trial falls improved innovation interdisciplinary collaboration interest meetings member novel novel marker outreach patient advocacy group posters prevent programs repository research study response sample collection statistics success tool tumor web site

项目摘要

The goal of the Leadership and Administration Core is to ensure that translational goals of the POCRC are met and that resources are used effectively. The Leadership Core is responsible for ongoing evaluation of scientific and translational progress of all projects. If progress is not sufficient, the Executive Committee comprised of Dr. Nicole Urban, Principal Investigator, and co-principal investigators, Drs. Mary (Nora) Disis, Charles Drescher, Beth Karlan, Steve Collins, and Martin (Mac) Cheever, will take necessary action. The Executive Committee is also responsible for ensuring that cores meet the needs of projects without redundancy or confiict, providing scientific leadership, facilitafing Inter-SPORE communication, coordinafing collaborations, integrating POCRC and CCSG activities, and allocating SPORE resources. The,Leadership Core will be responsible for coordinating SPORE activities and assuring communication between the cores, projects and committees. Committees within the Leadership Core will include representation from members ofthe Patient Advocate Group to make certain that the POCRC constanfiy works towards achieving its translational goals and meeting the needs ofthe patient. The Leadership Core will provide overall guidance for the translational activities ofthe SPORE, building on established interdisciplinary collaborations. It will promote, oversee, and evaluate active interaction between the cores and the projects. Through the advisory boards and committees, the Leadership Core will provide the following functions: 1) overall management and coordination ofthe SPORE; 2) meet the scientific advisory needs of the individual research projects; 3) oversee, plan, and evaluate SPORE acfivifies including inter¿ SPORE activities; 4) promote, oversee, and evaluate interaction of cores and projects; 5) encourage, select, and guide developmental projects; 6) provide mentoring and career development; 7) manage, distribute, and re-allocate SPORE funds and other resources as appropriate; 8) oversee IRB activity; 9) ensure that scientific objectives can ultimately be translated to patient care; 10) initiate new activities in response to important translational research opportunities. To address the needs of the projects and the cores, experts in ovarian cancer, translational research, early detection/screening, epidemiology, genomics, immunology, statistical methods, informatics, and pathology have been identified and recruited to serve in the Leadership Core. Senior leaders with relevant expertise will interact with each other on substantive committees as well as provide mentorship to POCRC investigators who are experts in their own fields but less acquainted with other disciplines that are critical to career development in ovarian cancer translational research and the overall success ofthe POCR(Z;. RELEVANCE (See instructions): The goal of this ovarian SPORE is to demonstrate better strategies for 1) screening high-risk women using novel serum markers and state-of-the-art imaging without the need for another large trial, by integrating our Phase I trial results with reports from ongoing Phase III efficacy trials; 2) selecting women for neoadjuvant therapy by testing their blood for a resectability signature; and 3) immunizing women against their own tumors to prevent recurrence. Success in one or more of these efforts will significantly reduce the burden of ovarian cancer.

领导力和管理核心的目标是确保POCRC的翻译目标是满足并有效地使用了资源。领导力核心负责持续评估所有项目的科学和翻译进展。如果进步还不够，执行委员会首席调查员兼联合主持调查员Nicole Urban博士完成。玛丽（诺拉）迪斯，查尔斯·德雷舍（Charles Drescher），贝丝·卡兰（Beth Karlan），史蒂夫·柯林斯（Steve Collins）和马丁（Mac）Cheever将采取必要的行动。这执行委员会还负责确保核心满足没有项目需求冗余或冲突，提供科学领导力，促进跨越跨越沟通，坐标合作，集成POCRC和CCSG活动以及分配孢子资源。领导力核心将负责协调孢子活动并确保交流在核心，项目和委员会之间。领导力核心内的委员会将包括患者倡导者小组成员的代表性确保POCRC CONSTANFIY 致力于实现其翻译目标并满足患者的需求。领导力核心将为既定的孢子的翻译活动提供总体指导跨学科合作。它将促进，监督和评估核心之间的主动相互作用和项目。通过咨询委员会和委员会，领导核心将提供以下功能：1）孢子的总体管理和协调； 2）符合科学咨询各个研究项目的需求； 3）监督，计划和评估包括Inter的孢子学分孢子活动； 4）促进，监督和评估核心与项目的相互作用； 5）鼓励，选择，并指导发展项目； 6）提供心理和职业发展； 7）管理，分发和重新分配孢子资金和其他资源； 8）监督IRB活动； 9）确保这一点科学目标最终可以转化为患者护理； 10）启动新活动以回应重要的翻译研究机会。为了满足项目和核心的需求，卵巢癌专家翻译研究，早期检测/筛查，流行病学，基因组学，免疫学，统计方法，信息和病理学已被确定并招募以在领导核心中服务。相关专家的高级领导者将在实体委员会上相互互动，并为POCRC提供精明权研究人员是自己领域的专家卵巢癌转化研究的职业发展和POCR的整体成功（Z;。相关性（请参阅说明）：该卵巢孢子的目的是为1）筛查高风险妇女使用更好的策略通过整合我们 I期试验结果以及正在进行的III期有效试验的报告； 2）为新辅助选择女性通过测试血液的可切除性特征来治疗； 3）妇女免疫自己防止复发的肿瘤。在其中一项或多项努力中的成功将大大减少燃烧卵巢癌。