Element labeling antibodies for bio-imaging of proteins: a case study of beta-amyloid in Alzheimer's disease mouse models

该项目将开发新的分析方法，用于小鼠大脑中β-淀粉样蛋白的定量原位成像。大脑中的β-淀粉样蛋白沉积与阿尔茨海默病有关。它还计划同时成像金属离子，这也涉及β-淀粉样蛋白的沉积。将这些新方法应用于阿尔茨海默病小鼠模型，将通过确定淀粉样蛋白和金属离子之间的关系，为阿尔茨海默病的病因学提供新的知识和重要的见解。

This project will develop new analytical methods for quantitative in-situ imaging of beta-amyloid in mouse brains. Beta-amyloid deposition in the brain is associated with Alzheimer�s disease. It is also planned to simultaneously image metal ions, which are also implicated in the deposition of beta-amyloid. Application of these novel methods to Alzheimer�s disease mouse models will provide new knowledge and significant insights into the aetiology of Alzheimer�s disease by determining the relationship between amyloid proteins and metal ions.