CORE--SIGNAL TRANSDUCTION RESEARCH FACILITY

本核心的长期目标是阐明 非遗传毒性的生物学反应机制 环境代理人。 核心的目标是：1）描绘信号 各种模型中的转导途径及其效应成分 系统：2）研究与 结果是通路、效应器或信号传递中断 暴露于环境因素;和3）以确定如何变化， 遗传背景影响正常的信号转导通路。 的 要解决的具体假设是，某些环境因素 通过干扰正常对照来改变基因表达 调节组织特异性受体和效应分子的机制， 第二信使的产生， 转录因子 该组织成员进行的研究表明， 来自四个不同部门的核心正在解决这些问题。

The long-term objective of this Core is to elucidate the molecular mechanisms underlying the biological responses to non-genotoxic environmental agents. The aims of the Core are: 1) to delineate signal transduction pathways and their effector components in various model systems: 2) to study the molecular mechanisms associated with the disruption of pathways, effectors, or signal transmission as a consequence of exposure to environmental agents; and 3) to determine how variations in genetic background affect normal signal transduction pathways. The specific hypothesis to be addressed is that certain environmental agents act to modify gene expression by interfering with the normal control mechanisms that regulate tissue-specific receptors and effector molecules, production of second messengers, and synthesis and activation of transcription factors. The research conducted by the members of this Core, from four different departments, are addressing these issues.