PSYCHOTHERAPY DEVELOPMENT RESEARCH CENTER

我们寻求更新我们的心理治疗研究中心，致力于药物滥用心理治疗的开发、评估和完善。组织的主题是心理治疗的发展和基于心理治疗研究的“技术模型”的实证检验(Carroll和Rounaville，1990)。该中心的目标是推动创新的药物滥用治疗方法的发展，从仅仅是“好主意”到能够广泛使用经验证的治疗方法。这一过程需要在循序渐进的阶段进行研究。第一阶段包括试点测试、手工编写和培训计划制定；第二阶段包括受控疗效试验；第三阶段包括评估有效治疗方法在一般临床实践中的普适性的研究。在中心最初4年的活动中，我们成功地实施了最初提出的6个成分研究项目，完成了15个试点项目，并指导7名新的当地研究人员开发了他们第一个外部支持的行为治疗研究项目。我们还作为心理治疗研究的全国资源，为耶鲁大学以外的14个资助项目的发展提供咨询，为8个主要的多地点行为和/或药物治疗疗效试验提供手动指导培训，开发培训包以促进更广泛地使用有效的药物滥用治疗，并向国家组织提供与心理治疗研究相关的方法学和战略问题的咨询。在更新期间，研究将继续围绕阶段模式组织，包括一个核心设施和7个单独的研究部分。核心工作人员将为中心项目提供科学监督、管理和技术援助，并为其他地点的研究人员和临床医生提供咨询和技术转让服务。三个第一阶段的项目将开发新的方法：为滥用药物的父亲提供父母关系干预，为双重诊断患者进行动机访谈，以及为可卡因滥用者提供情感调节疗法。三个第二阶段项目将评估以下项目的效果：十二步促进，以加强可卡因依赖的双硫仑，改善法院转介的大麻使用者的参与度和结果，以及改善对抗逆转录病毒药物的依从性。一个第三阶段项目将评估针对一般设置的低成本应急管理。

We seek to renew our psychotherapy research center dedicated to the development, evaluation and refinement of psychotherapies for drug abuse. The organizing theme is psychotherapy development and empirical testing based on the "technology model" of psychotherapy research (Carroll and Rounsaville, 1990). The Center's goal is to catalyze the development of innovative drug abuse treatments from the point where they are merely "good ideas" to one where they are capable of widespread use of empirically validated treatments. The process requires research at sequential, progressively demanding stages. Stage 1 consists of pilot testing, manual writing and training program development: Stage II consists of controlled efficacy trials; Stage III consists of studies to evaluate generalizability of efficacious treatments to general clinical practice. During the first 4 years of Center activities, we have successfully conducted the 6 originally proposed component research projects, completed 15 pilot projects and guide 7 new local investigators to develop their first externally supported research projects on behavioral treatment. We have also served as a national resource for psychotherapy research by consulting on development of 14 funded projects outside Yale, providing manual guided training for 8 major multisite behavioral and/or pharmacotherapy efficacy trials, developing training packages to foster more widespread use of efficacious substance abuse treatments and providing consultation on methodological and strategic issues related to psychotherapy research to national organization. During renewal period, research will continue to be organized around the stage model with a CORE facility and 7 individual research components. Core staff will provide scientific oversight, administration and technical assistance to Center projects and also provide consultation and technology transfer services to investigators and clinicians at other sites. Three Stage I projects will develop new approaches: A Relational Parent Intervention for Drug Abusing Fathers, Motivational Interviewing (MET) for Dual Diagnosis Patients and Affect Regulation Therapy for Cocaine Abusers. Three Stage II projects will evaluate efficacy of the following: Twelve Step Facilitation to Enhance Disulfiram for Cocaine Dependence, Improving Engagement & Outcome for Court-Referred Marijuana Users, and Improving Adherence to Anti-retroviral Medication. One Stage III project will evaluate Low-Cost Contingency Management for General Settings.