DRUG ABUSE PREVENTION - A LIFECOURSE PERSPECTIVE

描述：(申请人提供)大学预防研究中心 肯塔基大学以围绕 新奇/感觉寻求的建构(N/S)。在过去的12年里，我们 在多个互补的分析水平上评估N/S的寻求行为 并在我们对起病和死亡的理解上取得了长足的进步 药物滥用的发展，并将这一信息应用于发展 更有针对性和更有效的预防工作。我们的工作显然已经 受益于不同部门之间强有力的跨学科协作 补充实验室，既在中心内，也与其他正在进行的 肯塔基大学校区的项目。的三个具体目标 中心核心是(1)科学：生成和发布高质量的预防措施 在相关领域被公认为最先进的研究的科学 纪律；(2)组织性：提供智力激励， 创造性和生产性的环境，在其中研究问题和问题 从多层次、跨学科的角度进行审查；以及(3)领导力： 作为药物滥用和预防的资源、倡导者和领导者 科学，部分是通过培训下一代药物滥用预防 研究人员。 始终将科学家和研究项目联系在一起的实质性主题 一起在我们的中心是广泛和深入的关注N/S的寻求行为在 药物滥用的发生和发展，并将这些信息应用于 开展更有针对性和更有效的预防工作。三位一体 目前申请中提出的项目是否继续和扩展中心？S 持续评估N/S寻求对药物使用和滥用的影响。(1) 动物实验室：药物反应的个体差异：动物模型 (迈克·巴多，少年派)该项目将使用动物模型来研究 N/S寻求与苯丙胺奖赏的关系：指导性假设 就像滥用兴奋剂一样，这种新奇的东西激活了中脑边缘 多巴胺奖励系统。(2)人体化验室：药物滥用责任及 寻求感觉地位(汤姆·凯利，少年派)。这一项目将扩大研究范围。 团队？S之前的工作就是寻找N/S作为调解人之间的关系 药物剂量以及歧视性、强化和其他行为效应 大麻、尼古丁、酒精和哌醋甲酯的滥用责任。(3) 社区实验室：青少年综合药物预防(迪克·克莱顿， PI)。该项目将延续中心长期以来的评价传统 以学校为基础、以课程为导向的预防方案，并对 普及性和选择性相结合的综合预防方案 感觉价值成分。

DESCRIPTION: (provided by applicant) The Center for Prevention Research at the University of Kentucky is distinguished by thematic integration around the construct of novelty/sensation (N/S) seeking. Over the past 12 years, we have evaluated N/S seeking behavior at a number of complementary levels of analysis and have made considerable progress in our understanding of the onset and development of drug abuse, and in applying this information to the development of more focused and effective prevention efforts. Our work has clearly benefited from the strong interdisciplinary collaboration among distinct yet complementary laboratories, both within the Center and with other ongoing projects on the University of Kentucky campus. The three specific aims of the Center Core are (1) Scientific: To generate and publish high quality prevention science that is recognized as state-of-the-art research across relevant disciplines; (2) Organizational: To provide an intellectually stimulating, creative, and productive environment in which research questions and issues are examined from a multilevel, interdisciplinary perspective; and (3) Leadership: To serve as a resource, advocate and leader for drug abuse and prevention science, in part by training the next generation of drug abuse prevention researchers. The substantive theme that consistently links scientists and research projects together in our Center is a broad and in-depth focus on N/S seeking behavior in the onset and development of drug abuse, and in applying this information for the development of more focused and effective prevention efforts. The three projects proposed in the current application continue and extend the Center?s on-going evaluations of the effects of N/S seeking on drug use and abuse. (1) Animal Laboratory: Individual Differences in Drug Response: An Animal Model (Mike Bardo, PI). This project will use an animal model to study the relationship between N/S seeking and amphetamine reward; the guiding hypothesis is that novelty, similar to stimulant drugs of abuse, activates the mesolimbic dopamine reward system. (2) Human Laboratory: Drug Abuse Liability and Sensation Seeking Status (Tom Kelly, PI). This project will expand the research team?s prior work on N/S seeking as a moderator of the relationship between drug dose and the discriminative, reinforcing and other behavioral effects and abuse liability of marijuana, nicotine, alcohol and methylphenidate. (3) Community Laboratory: Comprehensive Drug Prevention for Youth (Dick Clayton, PI). This project will continue a long-standing Center tradition of evaluations of school-based, curriculum-driven prevention programs with the evaluation of a comprehensive prevention program featuring both universal and selective high sensation value components.