Synthesis of core-shell nanoparticles in microreactors

纳米粒子（NPs）在过去的几十年里引起了科学界的兴趣，目前正在进行大量的应用和探索。纳米颗粒位于块状固体和分子结构之间的边缘，由于其非常小的尺寸（1-100纳米），如极高的表面能，高面积体积比和量子限制效应，表现出非凡的性能。这种独特的化学和物理性质使它们在催化、生物医学成像和发光技术等广泛领域引起了人们的兴趣。尽管它们具有潜力，但在大规模应用中部署它们需要克服许多障碍。它们的高表面能意味着它们对团聚特别敏感。此外，大多数纳米颗粒合成目前都是在小规模的批量过程中进行的，而扩大反应的规模往往具有挑战性，限制了潜在的工业应用。为了解决这些问题，该项目旨在开发合成核/壳纳米粒子的新制造技术，其中外壳充当保护由所需材料组成的内核的屏障。为此，将探索微反应器中的流动合成，以最大限度地提高其高传热传质系数以及层流状态，从而为大规模工业生产开辟道路。

Nanoparticles (NPs) have attracted the scientific interest during the last decades, currently being used and explored for a large number of application. Lying at the edge between bulk solids and molecular structures, nanoparticles exhibit exceptional properties due to their very small size (1-100 nm) such as extremely high surface energy, high area to volume ratio and quantum confinement effects. Such unique chemical and physical properties makes them interesting in a wide range of fields, including catalysis, biomedical imaging and light emitting technologies.Despite their potential, their deployment in large scale application require the overcome of a number of hurdles. Their high surface energy means that they are particularly reactive and sensitive to agglomeration. Furthermore, most nanoparticle syntheses are currently carried out using batch procedures on small scales and the scale up of the reactions is often challenging, limiting potential industrial applications.In order to tackle those issues, this project aims at developing new manufacturing technologies for the synthesis of core/shell nanoparticle, where the outer shell acts as a barrier protecting the inner core composed of the desired material. For this, flow synthesis in microreactor will be explored to maximise their high heat and mass transfer coefficients as well as laminar flow regime, thereby opening up the way to a large scale industrial production.