Elucidating the critical roles of ILC1, NK cell and innate memory in immune protection

自然杀伤细胞是提供对抗感染和癌症的第一道防线的先天细胞。最近发现的一种新的先天性细胞群改变了我们对免疫保护所必需的早期事件的看法。了解这些细胞的作用至关重要，因为它们可能代表可行的治疗靶点。我们开发了独特的小鼠模型，以实验性地靶向这一群体，以确定它们是如何产生的，以及它们在对抗感染和癌症中的作用。

Natural killer cells are innate cells that provide first line defense against infection and cancer. The recent discovery of a novel innate cell population has modified our vision of the early events necessary for immune protection. Understanding the role of these cells is critical as they could represent viable therapeutic targets. We have developed unique mouse models to experimentally target this population to determine how they are generated and their role in combating infection and cancer.